CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimental data have demonstrated microglial proliferation as a...

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Detalles Bibliográficos
Autores principales: Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Daniela Ruiz, Eva, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A, Simmons, Camilla, Cash, Diana, Richardson, Jill, Jones, Declan N C, Lovestone, Simon, Gómez-Nicola, Diego, Perry, V Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794948/
https://www.ncbi.nlm.nih.gov/pubmed/31504240
http://dx.doi.org/10.1093/brain/awz241

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