Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells

Glioma, the most common and aggressive type of brain tumor, has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for glioma genesis, proliferation, resistance to chemoradiotherapy, and recurrence. Long non-coding RNAs (lncRNAs) have been viewed as a prospective novel target i...

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Detalles Bibliográficos
Autores principales: Wang, Lei, He, Zhengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795106/
https://www.ncbi.nlm.nih.gov/pubmed/31593561
http://dx.doi.org/10.12659/MSM.916040
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author Wang, Lei
He, Zhengwen
author_facet Wang, Lei
He, Zhengwen
author_sort Wang, Lei
collection PubMed
description Glioma, the most common and aggressive type of brain tumor, has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for glioma genesis, proliferation, resistance to chemoradiotherapy, and recurrence. Long non-coding RNAs (lncRNAs) have been viewed as a prospective novel target in glioma therapy in recent years due to their functional roles in GSC biological processes. However, how lncRNAs interact with GSCs and the underlining mechanisms associated with these interactions are not yet clear. In this review, we briefly illustrate recent advancements in the functional roles of lncRNA and their potential mechanisms in GSCs.
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spelling pubmed-67951062019-10-31 Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells Wang, Lei He, Zhengwen Med Sci Monit Review Articles Glioma, the most common and aggressive type of brain tumor, has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for glioma genesis, proliferation, resistance to chemoradiotherapy, and recurrence. Long non-coding RNAs (lncRNAs) have been viewed as a prospective novel target in glioma therapy in recent years due to their functional roles in GSC biological processes. However, how lncRNAs interact with GSCs and the underlining mechanisms associated with these interactions are not yet clear. In this review, we briefly illustrate recent advancements in the functional roles of lncRNA and their potential mechanisms in GSCs. International Scientific Literature, Inc. 2019-10-08 /pmc/articles/PMC6795106/ /pubmed/31593561 http://dx.doi.org/10.12659/MSM.916040 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Review Articles
Wang, Lei
He, Zhengwen
Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title_full Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title_fullStr Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title_full_unstemmed Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title_short Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells
title_sort functional roles of long non-coding rnas (lncrnas) in glioma stem cells
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795106/
https://www.ncbi.nlm.nih.gov/pubmed/31593561
http://dx.doi.org/10.12659/MSM.916040
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