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Crystal structure and catalytic mechanism of the essential m(1)G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa

The tRNA (m(1)G37) methyltransferase TrmD catalyzes m(1)G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about TrmD in Pseudomonas aeruginosa (PaTrmD), an i...

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Detalles Bibliográficos
Autores principales:	Jaroensuk, Juthamas, Wong, Yee Hwa, Zhong, Wenhe, Liew, Chong Wai, Maenpuen, Somchart, Sahili, Abbas E., Atichartpongkul, Sopapan, Chionh, Yok Hian, Nah, Qianhui, Thongdee, Narumon, McBee, Megan E., Prestwich, Erin G., DeMott, Michael S., Chaiyen, Pimchai, Mongkolsuk, Skorn, Dedon, Peter C., Lescar, Julien, Fuangthong, Mayuree
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795141/ https://www.ncbi.nlm.nih.gov/pubmed/31399541 http://dx.doi.org/10.1261/rna.066746.118

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