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Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients?
Introduction: Tamoxifen treatment has been shown to reduce the recurrence and mortality rates in hormone receptor-positive breast cancers independent from chemotherapy. This benefit increases with the prolongation of the use of tamoxifen but with increasing side effects. In this study, we aim to eva...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795370/ https://www.ncbi.nlm.nih.gov/pubmed/31632870 http://dx.doi.org/10.7759/cureus.5417 |
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author | Imamoglu, Goksen Inanc Eren, Tulay Arzu, Oguz Yıldırım, Nuriye Karacin, Cengiz Baylan, Burhan |
author_facet | Imamoglu, Goksen Inanc Eren, Tulay Arzu, Oguz Yıldırım, Nuriye Karacin, Cengiz Baylan, Burhan |
author_sort | Imamoglu, Goksen Inanc |
collection | PubMed |
description | Introduction: Tamoxifen treatment has been shown to reduce the recurrence and mortality rates in hormone receptor-positive breast cancers independent from chemotherapy. This benefit increases with the prolongation of the use of tamoxifen but with increasing side effects. In this study, we aim to evaluate the presence of urogenital symptoms in breast cancer patients on tamoxifen and compare them with those who are not on any hormonotherapy. Materials and methods: This study was performed on patients diagnosed as early-stage breast cancer. The study group consisted of hormone receptor-positive patients given tamoxifen as adjuvant hormonal therapy. The control group consisted of breast cancer patients who had no hormonotherapy. Patients with a complaint of urinary incontinence with onset after tamoxifen usage were evaluated with Urogenital Distress Inventory Short Form (UDI-6), Incontinence Impact Questionnaire Short Form (IIQ-7) and Incontinence Quality of Life Questionnaire (I-QOL). Results: A total of 137 early-stage breast cancer patients were included in this study; 74 estrogen receptor-positive patients on tamoxifen therapy (study group) and 63 hormone receptor-negative patients with no hormonotherapy (control group). The median age was 44 (30-65) years for tamoxifen users and 49 (27-64) years for the control group. The stages of the patients were similar for both groups. 78.4% of the women in the tamoxifen group and 49.2% in the control group were in the premenopausal period. The groups were similar in regard to body mass index and parity. The complaint of urinary incontinence was more frequent in the study group compared to controls (39 (52.7%) vs. 5 (7.9%)). Women with the complaint of urinary incontinence were evaluated with self-reported UDI-6, IIQ-7 and I-QOL forms and the scores were similar for both study and control groups. A statistically significant relation was observed between cigarette smoking and the presence of urinary incontinence. The percentages of smokers were 50% of those with incontinence and 24.7% of those without incontinence. Conclusion: Urinary incontinence is positively correlated with tamoxifen usage in early-stage breast cancer patients. |
format | Online Article Text |
id | pubmed-6795370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-67953702019-10-19 Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? Imamoglu, Goksen Inanc Eren, Tulay Arzu, Oguz Yıldırım, Nuriye Karacin, Cengiz Baylan, Burhan Cureus Urology Introduction: Tamoxifen treatment has been shown to reduce the recurrence and mortality rates in hormone receptor-positive breast cancers independent from chemotherapy. This benefit increases with the prolongation of the use of tamoxifen but with increasing side effects. In this study, we aim to evaluate the presence of urogenital symptoms in breast cancer patients on tamoxifen and compare them with those who are not on any hormonotherapy. Materials and methods: This study was performed on patients diagnosed as early-stage breast cancer. The study group consisted of hormone receptor-positive patients given tamoxifen as adjuvant hormonal therapy. The control group consisted of breast cancer patients who had no hormonotherapy. Patients with a complaint of urinary incontinence with onset after tamoxifen usage were evaluated with Urogenital Distress Inventory Short Form (UDI-6), Incontinence Impact Questionnaire Short Form (IIQ-7) and Incontinence Quality of Life Questionnaire (I-QOL). Results: A total of 137 early-stage breast cancer patients were included in this study; 74 estrogen receptor-positive patients on tamoxifen therapy (study group) and 63 hormone receptor-negative patients with no hormonotherapy (control group). The median age was 44 (30-65) years for tamoxifen users and 49 (27-64) years for the control group. The stages of the patients were similar for both groups. 78.4% of the women in the tamoxifen group and 49.2% in the control group were in the premenopausal period. The groups were similar in regard to body mass index and parity. The complaint of urinary incontinence was more frequent in the study group compared to controls (39 (52.7%) vs. 5 (7.9%)). Women with the complaint of urinary incontinence were evaluated with self-reported UDI-6, IIQ-7 and I-QOL forms and the scores were similar for both study and control groups. A statistically significant relation was observed between cigarette smoking and the presence of urinary incontinence. The percentages of smokers were 50% of those with incontinence and 24.7% of those without incontinence. Conclusion: Urinary incontinence is positively correlated with tamoxifen usage in early-stage breast cancer patients. Cureus 2019-08-18 /pmc/articles/PMC6795370/ /pubmed/31632870 http://dx.doi.org/10.7759/cureus.5417 Text en Copyright © 2019, Imamoglu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Urology Imamoglu, Goksen Inanc Eren, Tulay Arzu, Oguz Yıldırım, Nuriye Karacin, Cengiz Baylan, Burhan Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title | Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title_full | Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title_fullStr | Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title_full_unstemmed | Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title_short | Is Tamoxifen Use a Factor Affecting Continence in Breast Cancer Patients? |
title_sort | is tamoxifen use a factor affecting continence in breast cancer patients? |
topic | Urology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795370/ https://www.ncbi.nlm.nih.gov/pubmed/31632870 http://dx.doi.org/10.7759/cureus.5417 |
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