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Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice

The goal of this study was to investigate the effects of acute cocaine injection or dopamine (DA) receptor antagonists on the medial prefrontal cortex (mPFC) gamma oscillations and their relationship to short term neuroadaptation that may mediate addiction. For this purpose, optogenetically evoked l...

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Autores principales: Oprisan, Sorinel A., Clementsmith, Xandre, Tompa, Tamas, Lavin, Antonieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795423/
https://www.ncbi.nlm.nih.gov/pubmed/31618234
http://dx.doi.org/10.1371/journal.pone.0223469
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author Oprisan, Sorinel A.
Clementsmith, Xandre
Tompa, Tamas
Lavin, Antonieta
author_facet Oprisan, Sorinel A.
Clementsmith, Xandre
Tompa, Tamas
Lavin, Antonieta
author_sort Oprisan, Sorinel A.
collection PubMed
description The goal of this study was to investigate the effects of acute cocaine injection or dopamine (DA) receptor antagonists on the medial prefrontal cortex (mPFC) gamma oscillations and their relationship to short term neuroadaptation that may mediate addiction. For this purpose, optogenetically evoked local field potentials (LFPs) in response to a brief 10 ms laser light pulse were recorded from 17 mice. D1-like receptor antagonist SCH 23390 or D2-like receptor antagonist sulpiride, or both, were administered either before or after cocaine. A Euclidian distance-based dendrogram classifier separated the 100 trials for each animal in disjoint clusters. When baseline and DA receptor antagonists trials were combined in a single trial, a minimum of 20% overlap occurred in some dendrogram clusters, which suggests a possible common, invariant, dynamic mechanism shared by both baseline and DA receptor antagonists data. The delay-embedding method of neural activity reconstruction was performed using the correlation time and mutual information to determine the lag/correlation time of LFPs and false nearest neighbors to determine the embedding dimension. We found that DA receptor antagonists applied before cocaine cancels out the effect of cocaine and leaves the lag time distributions at baseline values. On the other hand, cocaine applied after DA receptor antagonists shifts the lag time distributions to longer durations, i.e. increase the correlation time of LFPs. Fourier analysis showed that a reasonable accurate decomposition of the LFP data can be obtained with a relatively small (less than ten) Fourier coefficients.
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spelling pubmed-67954232019-10-20 Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice Oprisan, Sorinel A. Clementsmith, Xandre Tompa, Tamas Lavin, Antonieta PLoS One Research Article The goal of this study was to investigate the effects of acute cocaine injection or dopamine (DA) receptor antagonists on the medial prefrontal cortex (mPFC) gamma oscillations and their relationship to short term neuroadaptation that may mediate addiction. For this purpose, optogenetically evoked local field potentials (LFPs) in response to a brief 10 ms laser light pulse were recorded from 17 mice. D1-like receptor antagonist SCH 23390 or D2-like receptor antagonist sulpiride, or both, were administered either before or after cocaine. A Euclidian distance-based dendrogram classifier separated the 100 trials for each animal in disjoint clusters. When baseline and DA receptor antagonists trials were combined in a single trial, a minimum of 20% overlap occurred in some dendrogram clusters, which suggests a possible common, invariant, dynamic mechanism shared by both baseline and DA receptor antagonists data. The delay-embedding method of neural activity reconstruction was performed using the correlation time and mutual information to determine the lag/correlation time of LFPs and false nearest neighbors to determine the embedding dimension. We found that DA receptor antagonists applied before cocaine cancels out the effect of cocaine and leaves the lag time distributions at baseline values. On the other hand, cocaine applied after DA receptor antagonists shifts the lag time distributions to longer durations, i.e. increase the correlation time of LFPs. Fourier analysis showed that a reasonable accurate decomposition of the LFP data can be obtained with a relatively small (less than ten) Fourier coefficients. Public Library of Science 2019-10-16 /pmc/articles/PMC6795423/ /pubmed/31618234 http://dx.doi.org/10.1371/journal.pone.0223469 Text en © 2019 Oprisan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Oprisan, Sorinel A.
Clementsmith, Xandre
Tompa, Tamas
Lavin, Antonieta
Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title_full Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title_fullStr Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title_full_unstemmed Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title_short Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
title_sort dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795423/
https://www.ncbi.nlm.nih.gov/pubmed/31618234
http://dx.doi.org/10.1371/journal.pone.0223469
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