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Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms

Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restri...

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Detalles Bibliográficos
Autores principales:	Bahhir, Diana, Yalgin, Cagri, Ots, Liina, Järvinen, Sampsa, George, Jack, Naudí, Alba, Krama, Tatjana, Krams, Indrikis, Tamm, Mairi, Andjelković, Ana, Dufour, Eric, González de Cózar, Jose M., Gerards, Mike, Parhiala, Mikael, Pamplona, Reinald, Jacobs, Howard T., Jõers, Priit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795474/ https://www.ncbi.nlm.nih.gov/pubmed/31584940 http://dx.doi.org/10.1371/journal.pgen.1008410

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