Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

PIP(3)-dependent Rac exchanger 1 (P-Rex1) is activated downstream of G protein–coupled receptors to promote neutrophil migration and metastasis. The structure of more than half of the enzyme and its regulatory G protein binding site are unknown. Our 3.2 Å cryo-EM structure of the P-Rex1–Gβγ complex...

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Detalles Bibliográficos
Autores principales: Cash, Jennifer N., Urata, Sarah, Li, Sheng, Ravala, Sandeep K., Avramova, Larisa V., Shost, Michael D., Gutkind, J. Silvio, Tesmer, John J. G., Cianfrocco, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795519/
https://www.ncbi.nlm.nih.gov/pubmed/31663027
http://dx.doi.org/10.1126/sciadv.aax8855

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