Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

Protein misfolding and aggregation are associated with a many human disorders, including Alzheimer’s and Parkinson’s diseases. Toward increasing the effectiveness of early-stage drug discovery for these conditions, we report a bacterial platform that enables the biosynthesis of molecular libraries w...

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Detalles Bibliográficos
Autores principales: Delivoria, Dafni C., Chia, Sean, Habchi, Johnny, Perni, Michele, Matis, Ilias, Papaevgeniou, Nikoletta, Reczko, Martin, Chondrogianni, Niki, Dobson, Christopher M., Vendruscolo, Michele, Skretas, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795521/
https://www.ncbi.nlm.nih.gov/pubmed/31663025
http://dx.doi.org/10.1126/sciadv.aax5108

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