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Regiodivergent enantioselective C–H functionalization of Boc-1,3-oxazinanes and application to the synthesis of β(2) and β(3)-amino acids
β(2)- and β(3)-Amino acids are important chiral building blocks for the design of new pharmaceuticals and peptidomimetics. Here we report a straightforward regio- and enantiodivergent access to these compounds using a one-pot reaction composed of sparteine-mediated enantioselective lithiation of a B...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795538/ https://www.ncbi.nlm.nih.gov/pubmed/31620675 http://dx.doi.org/10.1038/s41929-019-0336-1 |