Evaluation of the potential for QTc prolongation with avelumab

PURPOSE: To report integrated electrocardiogram (ECG) summary and exposure–QTc analyses for avelumab, a human immunoglobulin G1 monoclonal antibody that binds programmed cell death 1 ligand 1, to assess potential effects on cardiac repolarization. METHODS: Data were pooled from three-phase 1/2 studi...

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Detalles Bibliográficos
Autores principales: Vugmeyster, Yulia, Güzel, Gülseren, Hennessy, Meliessa, Loos, Anja H., Dai, Haiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795609/
https://www.ncbi.nlm.nih.gov/pubmed/31478078
http://dx.doi.org/10.1007/s00280-019-03925-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795609/
https://www.ncbi.nlm.nih.gov/pubmed/31478078
http://dx.doi.org/10.1007/s00280-019-03925-z

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