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Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture
SUMMARY: In a population-based study of older Swedish women, we investigated if clinical vertebral fracture was associated with lower health-related quality of life (HRQoL) and determined whether the association remained over time. Clinical vertebral fracture was associated with lower HRQoL and the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795611/ https://www.ncbi.nlm.nih.gov/pubmed/31227884 http://dx.doi.org/10.1007/s00198-019-05044-0 |
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author | Johansson, L. Svensson, H. K. Karlsson, J. Olsson, L.-E. Mellström, D. Lorentzon, M. Sundh, D. |
author_facet | Johansson, L. Svensson, H. K. Karlsson, J. Olsson, L.-E. Mellström, D. Lorentzon, M. Sundh, D. |
author_sort | Johansson, L. |
collection | PubMed |
description | SUMMARY: In a population-based study of older Swedish women, we investigated if clinical vertebral fracture was associated with lower health-related quality of life (HRQoL) and determined whether the association remained over time. Clinical vertebral fracture was associated with lower HRQoL and the effect persisted for up to 18.9 years. INTRODUCTION: Vertebral fractures are often associated with back pain and reduced physical function, which might result in isolation and depression. As a result, women with vertebral fractures often have lower health-related quality of life (HRQoL), but during what time frame the decrease lingers is unclear. Therefore, the aim of this study was to investigate if clinical vertebral fracture and hip fracture were associated with lower HRQoL and to determine whether the associations remained over time. METHODS: Vertebral fracture assessments (VFA) were performed using dual-energy X-ray absorptiometry. Data regarding prior fractures, medications, medical history, and physical activity was collected using a questionnaire. Self-rated physical HRQoL was assessed using the 12-Item Short-Form Health Survey (SF-12). Women with clinical vertebral fractures were divided into tertiles according to time since fracture onset and their HRQoL was compared with non-fractured women. RESULTS: In a population-based cross-sectional study of 3028 women aged 77.8 ± 1.63 (mean ± SD), a total of 130 (4.3%) women reported at least one clinical vertebral fracture. Women with a clinical vertebral fracture, divided into tertiles (T1–T3) depending on time since the fracture occurred, had lower HRQoL (T1: 36.3 ± 10.8; T2: 41.0 ± 9.94; and T3:41.6 ± 11.4) than women without fracture (46.2 ± 10.6; p < 0.001). Using linear regression analysis, clinical vertebral fracture was associated with reduced physical HRQoL for up to 18.9 years, independently of covariates (age, height, weight, smoking, prior stroke, mental HRQoL, grip strength, and lumbar spine BMD). CONCLUSIONS: Clinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9 years after time of fracture. |
format | Online Article Text |
id | pubmed-6795611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-67956112019-10-25 Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture Johansson, L. Svensson, H. K. Karlsson, J. Olsson, L.-E. Mellström, D. Lorentzon, M. Sundh, D. Osteoporos Int Original Article SUMMARY: In a population-based study of older Swedish women, we investigated if clinical vertebral fracture was associated with lower health-related quality of life (HRQoL) and determined whether the association remained over time. Clinical vertebral fracture was associated with lower HRQoL and the effect persisted for up to 18.9 years. INTRODUCTION: Vertebral fractures are often associated with back pain and reduced physical function, which might result in isolation and depression. As a result, women with vertebral fractures often have lower health-related quality of life (HRQoL), but during what time frame the decrease lingers is unclear. Therefore, the aim of this study was to investigate if clinical vertebral fracture and hip fracture were associated with lower HRQoL and to determine whether the associations remained over time. METHODS: Vertebral fracture assessments (VFA) were performed using dual-energy X-ray absorptiometry. Data regarding prior fractures, medications, medical history, and physical activity was collected using a questionnaire. Self-rated physical HRQoL was assessed using the 12-Item Short-Form Health Survey (SF-12). Women with clinical vertebral fractures were divided into tertiles according to time since fracture onset and their HRQoL was compared with non-fractured women. RESULTS: In a population-based cross-sectional study of 3028 women aged 77.8 ± 1.63 (mean ± SD), a total of 130 (4.3%) women reported at least one clinical vertebral fracture. Women with a clinical vertebral fracture, divided into tertiles (T1–T3) depending on time since the fracture occurred, had lower HRQoL (T1: 36.3 ± 10.8; T2: 41.0 ± 9.94; and T3:41.6 ± 11.4) than women without fracture (46.2 ± 10.6; p < 0.001). Using linear regression analysis, clinical vertebral fracture was associated with reduced physical HRQoL for up to 18.9 years, independently of covariates (age, height, weight, smoking, prior stroke, mental HRQoL, grip strength, and lumbar spine BMD). CONCLUSIONS: Clinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9 years after time of fracture. Springer London 2019-06-21 2019 /pmc/articles/PMC6795611/ /pubmed/31227884 http://dx.doi.org/10.1007/s00198-019-05044-0 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Johansson, L. Svensson, H. K. Karlsson, J. Olsson, L.-E. Mellström, D. Lorentzon, M. Sundh, D. Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title | Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title_full | Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title_fullStr | Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title_full_unstemmed | Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title_short | Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
title_sort | decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795611/ https://www.ncbi.nlm.nih.gov/pubmed/31227884 http://dx.doi.org/10.1007/s00198-019-05044-0 |
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