Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been shown to increase the risk of developing Alzheimer’s disease (AD) supporting a role of microglia and immune cells in the pathobiology of AD. We have employed an ectopic model of TREM2 and DAP12 express...

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Detalles Bibliográficos
Autores principales: Yao, Hailan, Coppola, Kyle, Schweig, Jonas Elias, Crawford, Fiona, Mullan, Michael, Paris, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795686/
https://www.ncbi.nlm.nih.gov/pubmed/31649511
http://dx.doi.org/10.3389/fncel.2019.00457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795686/
https://www.ncbi.nlm.nih.gov/pubmed/31649511
http://dx.doi.org/10.3389/fncel.2019.00457

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