Cargando…
Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
Several genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) have been shown to increase the risk of developing Alzheimer’s disease (AD) supporting a role of microglia and immune cells in the pathobiology of AD. We have employed an ectopic model of TREM2 and DAP12 express...
Autores principales: | Yao, Hailan, Coppola, Kyle, Schweig, Jonas Elias, Crawford, Fiona, Mullan, Michael, Paris, Daniel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795686/ https://www.ncbi.nlm.nih.gov/pubmed/31649511 http://dx.doi.org/10.3389/fncel.2019.00457 |
Ejemplares similares
-
Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
por: Schweig, Jonas Elias, et al.
Publicado: (2017) -
Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017) -
Corrigendum: Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017) -
MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease
por: Ringland, Charis, et al.
Publicado: (2021) -
TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
por: Gouna, Garyfallia, et al.
Publicado: (2021)