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Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells. However, some cancers have shown to be particularly radioresistant partly because of efficient and redundant DNA repair capacities. There...

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Autores principales: Biau, Julian, Chautard, Emmanuel, Verrelle, Pierre, Dutreix, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795692/
https://www.ncbi.nlm.nih.gov/pubmed/31649878
http://dx.doi.org/10.3389/fonc.2019.01009
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author Biau, Julian
Chautard, Emmanuel
Verrelle, Pierre
Dutreix, Marie
author_facet Biau, Julian
Chautard, Emmanuel
Verrelle, Pierre
Dutreix, Marie
author_sort Biau, Julian
collection PubMed
description Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells. However, some cancers have shown to be particularly radioresistant partly because of efficient and redundant DNA repair capacities. Therefore, RT efficacy might be enhanced by using drugs that can disrupt cancer cells' DNA repair machinery. Here we review the recent advances in the development of novel inhibitors of DNA repair pathways in combination with RT. A large number of these compounds are the subject of preclinical/clinical studies and target key enzymes involved in one or more DNA repair pathways. A totally different strategy consists of mimicking DNA double-strand breaks via small interfering DNA (siDNA) to bait the whole DNA repair machinery, leading to its global inhibition.
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spelling pubmed-67956922019-10-24 Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting Biau, Julian Chautard, Emmanuel Verrelle, Pierre Dutreix, Marie Front Oncol Oncology Radiation therapy (RT) is widely used in cancer care strategies. Its effectiveness relies mainly on its ability to cause lethal damage to the DNA of cancer cells. However, some cancers have shown to be particularly radioresistant partly because of efficient and redundant DNA repair capacities. Therefore, RT efficacy might be enhanced by using drugs that can disrupt cancer cells' DNA repair machinery. Here we review the recent advances in the development of novel inhibitors of DNA repair pathways in combination with RT. A large number of these compounds are the subject of preclinical/clinical studies and target key enzymes involved in one or more DNA repair pathways. A totally different strategy consists of mimicking DNA double-strand breaks via small interfering DNA (siDNA) to bait the whole DNA repair machinery, leading to its global inhibition. Frontiers Media S.A. 2019-10-10 /pmc/articles/PMC6795692/ /pubmed/31649878 http://dx.doi.org/10.3389/fonc.2019.01009 Text en Copyright © 2019 Biau, Chautard, Verrelle and Dutreix. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Biau, Julian
Chautard, Emmanuel
Verrelle, Pierre
Dutreix, Marie
Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title_full Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title_fullStr Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title_full_unstemmed Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title_short Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
title_sort altering dna repair to improve radiation therapy: specific and multiple pathway targeting
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795692/
https://www.ncbi.nlm.nih.gov/pubmed/31649878
http://dx.doi.org/10.3389/fonc.2019.01009
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