Cargando…

Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report

BACKGROUND: Cardiac tumors are rare and complex entities. Surgery represents the cornerstone of therapy, while the role of adjuvant treatment remains unclear and, in case of relapse or metastatic disease, the prognosis is very poor. Lack of prospective, randomized clinical trials hinders the generat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saponara, Maristella, Indio, Valentina, Pizzi, Carmine, Serban, Elena-Daniela, Urbini, Milena, Astolfi, Annalisa, Paolisso, Pasquale, Suarez, Sofia Martin, Nannini, Margherita, Pacini, Davide, Agostini, Valentina, Leone, Ornella, Ambrosini, Valentina, Tarantino, Giuseppe, Fanti, Stefano, Niro, Fabio, Buia, Francesco, Attinà, Domenico, Pantaleo, Maria Abbondanza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2019
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795718/ https://www.ncbi.nlm.nih.gov/pubmed/31624749 http://dx.doi.org/10.12998/wjcc.v7.i19.3018

Ejemplares similares

Genetic aberrations and molecular biology of cardiac sarcoma
por: Urbini, Milena, et al.
Publicado: (2020)

(18)F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature
por: Saponara, Maristella, et al.
Publicado: (2018)

The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor
por: Astolfi, Annalisa, et al.
Publicado: (2020)

Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation
por: Indio, Valentina, et al.
Publicado: (2020)

Primary malignant pericardial tumour in Lynch syndrome
por: Paolisso, Pasquale, et al.
Publicado: (2020)

Genomic Characterization of Rare Primary Cardiac Sarcoma Entities
por: Gozzellino, Livia, et al.
Publicado: (2023)

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST
por: Astolfi, Annalisa, et al.
Publicado: (2020)

The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)
por: Rizzo, Alessandro, et al.
Publicado: (2021)

SRF Rearrangements in Soft Tissue Tumors with Muscle Differentiation
por: Costa, Alice, et al.
Publicado: (2022)

Paratesticular Mesenchymal Malignancies: A Single-Center Case Series, Clinical Management, and Review of Literature
por: Gatto, Lidia, et al.
Publicado: (2020)

Gain of FGF4 is a frequent event in KIT/PDGFRA/SDH/RAS‐P WT GIST
por: Urbini, Milena, et al.
Publicado: (2019)

Whole exome sequencing (WES) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue in gastrointestinal stromal tumors (GIST)
por: Astolfi, Annalisa, et al.
Publicado: (2015)

Targeted therapy in SDH-deficient GIST
por: Nannini, Margherita, et al.
Publicado: (2021)

Case Report: The Complete Remission of a Mixed Germ Cell Tumor With Somatic Type Malignancy of Sarcoma Type With a GCT-Oriented Therapy: Clinical Findings and Genomic Profiling
por: Pantaleo, Maria A., et al.
Publicado: (2021)

Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib
por: Nannini, Margherita, et al.
Publicado: (2019)

Integrated Molecular Characterization of Gastrointestinal Stromal Tumors (GIST) Harboring the Rare D842V Mutation in PDGFRA Gene
por: Indio, Valentina, et al.
Publicado: (2018)

Dystrophin deregulation is associated with tumor progression in KIT/PDGFRA mutant gastrointestinal stromal tumors
por: Pantaleo, Maria A, et al.
Publicado: (2014)

Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors
por: Indio, Valentina, et al.
Publicado: (2021)

Whole Exome Sequencing Uncovers Germline Variants of Cancer-Related Genes in Sporadic Pheochromocytoma
por: Urbini, Milena, et al.
Publicado: (2018)

Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)
por: Saponara, Maristella, et al.
Publicado: (2015)

Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma
por: Urbini, Milena, et al.
Publicado: (2018)

Identification of SRF-E2F1 fusion transcript in EWSR-negative myoepithelioma of the soft tissue
por: Urbini, Milena, et al.
Publicado: (2017)

Current status of the adjuvant therapy in uterine sarcoma: A literature review
por: Rizzo, Alessandro, et al.
Publicado: (2019)

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
por: Nannini, Margherita, et al.
Publicado: (2014)

Immune microenvironment profiling of gastrointestinal stromal tumors (GIST) shows gene expression patterns associated to immune checkpoint inhibitors response
por: Pantaleo, Maria A., et al.
Publicado: (2019)

Genomic Database Analysis of Uterine Leiomyosarcoma Mutational Profile
por: Astolfi, Annalisa, et al.
Publicado: (2020)

SDHC methylation in gastrointestinal stromal tumors (GIST): a case report
por: Urbini, Milena, et al.
Publicado: (2015)

Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST
por: Urbini, Milena, et al.
Publicado: (2020)

Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib
por: Pantaleo, Maria Abbondanza, et al.
Publicado: (2012)

miRNA Expression May Have Implications for Immunotherapy in PDGFRA Mutant GISTs
por: Ravegnini, Gloria, et al.
Publicado: (2022)

Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis
por: Rizzo, Alessandro, et al.
Publicado: (2020)

Complete radiological response to first-line regorafenib in a patient with abdominal relapse of BRAF V600E mutated GIST
por: Nannini, Margherita, et al.
Publicado: (2020)

SDHA Germline Variants in Adult Patients With SDHA-Mutant Gastrointestinal Stromal Tumor
por: Pantaleo, Maria A., et al.
Publicado: (2022)

Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor
por: Lolli, Cristian, et al.
Publicado: (2011)

Alternative schedules or integration strategies to maximise treatment duration with sunitinib in patients with gastrointestinal stromal tumours
por: SAPONARA, MARISTELLA, et al.
Publicado: (2014)

Liquid biopsy in gastrointestinal stromal tumors: a novel approach
por: Nannini, Margherita, et al.
Publicado: (2014)

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
por: Nannini, Margherita, et al.
Publicado: (2017)

Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets
por: Ravegnini, Gloria, et al.
Publicado: (2019)

Preclinical Models of Visceral Sarcomas
por: Costa, Alice, et al.
Publicado: (2023)

Personalization of regorafenib treatment in metastatic gastrointestinal stromal tumours in real-life clinical practice
por: Nannini, Margherita, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ernplqip3lovsd077k1ttm52g7