N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N(6)-methyladenosine (m(6)A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metas...

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Detalles Bibliográficos
Autores principales: Chen, Ri-Xin, Chen, Xin, Xia, Liang-Ping, Zhang, Jia-Xing, Pan, Zhi-Zhong, Ma, Xiao-Dan, Han, Kai, Chen, Jie-Wei, Judde, Jean-Gabrie, Deas, Olivier, Wang, Feng, Ma, Ning-Fang, Guan, Xinyuan, Yun, Jing-Ping, Wang, Feng-Wei, Xu, Rui-Hua, Dan Xie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795808/
https://www.ncbi.nlm.nih.gov/pubmed/31619685
http://dx.doi.org/10.1038/s41467-019-12651-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795808/
https://www.ncbi.nlm.nih.gov/pubmed/31619685
http://dx.doi.org/10.1038/s41467-019-12651-2

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