Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice

Metabolism is a major defense mechanism of the body against xenobiotic threats. Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 deficiency decreases the mRNA, protein and microsomal activity of Cyp3a11, and blunts their circ...

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Detalles Bibliográficos
Autores principales: Lin, Yanke, Wang, Shuai, Zhou, Ziyue, Guo, Lianxia, Yu, Fangjun, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795895/
https://www.ncbi.nlm.nih.gov/pubmed/31633069
http://dx.doi.org/10.1038/s42003-019-0607-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795895/
https://www.ncbi.nlm.nih.gov/pubmed/31633069
http://dx.doi.org/10.1038/s42003-019-0607-z

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