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Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing

Human pluripotent stem cells (hPSCs) have significant levels of low-grade genetic mosaicism, which commonly used techniques fail to detect in bulk DNA. These copy number variations remain a hurdle for the clinical translation of hPSC, as their effect in vivo ranges from unknown to dangerous, and the...

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Detalles Bibliográficos
Autores principales:	Keller, Alexander, Tilleman, Laurentijn, Dziedzicka, Dominika, Zambelli, Filippo, Sermon, Karen, Van Nieuwerburgh, Filip, Spits, Claudia, Geens, Mieke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796059/ https://www.ncbi.nlm.nih.gov/pubmed/31619727 http://dx.doi.org/10.1038/s41598-019-51314-6

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