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Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection

Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fi...

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Autores principales: MARUYAMA, Keisuke, YOKOI, Hidenori, NAGASE, Miki, YOSHIDA, Hiroki, NOGUCHI, Akio, MATSUMURA, George, SAITO, Koichiro, SHIOKAWA, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796061/
https://www.ncbi.nlm.nih.gov/pubmed/31270286
http://dx.doi.org/10.2176/nmc.oa.2019-0069
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author MARUYAMA, Keisuke
YOKOI, Hidenori
NAGASE, Miki
YOSHIDA, Hiroki
NOGUCHI, Akio
MATSUMURA, George
SAITO, Koichiro
SHIOKAWA, Yoshiaki
author_facet MARUYAMA, Keisuke
YOKOI, Hidenori
NAGASE, Miki
YOSHIDA, Hiroki
NOGUCHI, Akio
MATSUMURA, George
SAITO, Koichiro
SHIOKAWA, Yoshiaki
author_sort MARUYAMA, Keisuke
collection PubMed
description Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fixation method using N-vinyl-2-pyrrolidone (NVP), a precursor of the water-soluble macromolecular polymer, for endoscopic transnasal skull base approach in six donated cadaver specimens. In four cadavers, elasticity of the soft tissue in the nasal cavity was almost similar to that of living tissue, and a surgical approach similar to the real surgical field was possible. However, the soft tissue was moderately stiffer than living tissue in two specimens so that surgical manipulation was hindered to some extent while NVP concentration was 10% in all the cadavers. Since the brain tissue was too soft and pliable for surgical manipulation in NVP, more careful surgical manipulation than real surgical field was mandatory in order to prevent damage in the brain tissue. Therefore, this concentration of NVP was considered to be appropriate. In conclusion, NVP embalming was effective for endoscopic transnasal skull base approach in cadaver dissection, providing environment similar to the real surgical field.
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spelling pubmed-67960612019-10-17 Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection MARUYAMA, Keisuke YOKOI, Hidenori NAGASE, Miki YOSHIDA, Hiroki NOGUCHI, Akio MATSUMURA, George SAITO, Koichiro SHIOKAWA, Yoshiaki Neurol Med Chir (Tokyo) Original Article Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fixation method using N-vinyl-2-pyrrolidone (NVP), a precursor of the water-soluble macromolecular polymer, for endoscopic transnasal skull base approach in six donated cadaver specimens. In four cadavers, elasticity of the soft tissue in the nasal cavity was almost similar to that of living tissue, and a surgical approach similar to the real surgical field was possible. However, the soft tissue was moderately stiffer than living tissue in two specimens so that surgical manipulation was hindered to some extent while NVP concentration was 10% in all the cadavers. Since the brain tissue was too soft and pliable for surgical manipulation in NVP, more careful surgical manipulation than real surgical field was mandatory in order to prevent damage in the brain tissue. Therefore, this concentration of NVP was considered to be appropriate. In conclusion, NVP embalming was effective for endoscopic transnasal skull base approach in cadaver dissection, providing environment similar to the real surgical field. The Japan Neurosurgical Society 2019-10 2019-07-04 /pmc/articles/PMC6796061/ /pubmed/31270286 http://dx.doi.org/10.2176/nmc.oa.2019-0069 Text en © 2019 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
MARUYAMA, Keisuke
YOKOI, Hidenori
NAGASE, Miki
YOSHIDA, Hiroki
NOGUCHI, Akio
MATSUMURA, George
SAITO, Koichiro
SHIOKAWA, Yoshiaki
Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title_full Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title_fullStr Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title_full_unstemmed Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title_short Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
title_sort usefulness of n-vinyl-2-pyrrolidone embalming for endoscopic transnasal skull base approach in cadaver dissection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796061/
https://www.ncbi.nlm.nih.gov/pubmed/31270286
http://dx.doi.org/10.2176/nmc.oa.2019-0069
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