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Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection
Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japan Neurosurgical Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796061/ https://www.ncbi.nlm.nih.gov/pubmed/31270286 http://dx.doi.org/10.2176/nmc.oa.2019-0069 |
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author | MARUYAMA, Keisuke YOKOI, Hidenori NAGASE, Miki YOSHIDA, Hiroki NOGUCHI, Akio MATSUMURA, George SAITO, Koichiro SHIOKAWA, Yoshiaki |
author_facet | MARUYAMA, Keisuke YOKOI, Hidenori NAGASE, Miki YOSHIDA, Hiroki NOGUCHI, Akio MATSUMURA, George SAITO, Koichiro SHIOKAWA, Yoshiaki |
author_sort | MARUYAMA, Keisuke |
collection | PubMed |
description | Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fixation method using N-vinyl-2-pyrrolidone (NVP), a precursor of the water-soluble macromolecular polymer, for endoscopic transnasal skull base approach in six donated cadaver specimens. In four cadavers, elasticity of the soft tissue in the nasal cavity was almost similar to that of living tissue, and a surgical approach similar to the real surgical field was possible. However, the soft tissue was moderately stiffer than living tissue in two specimens so that surgical manipulation was hindered to some extent while NVP concentration was 10% in all the cadavers. Since the brain tissue was too soft and pliable for surgical manipulation in NVP, more careful surgical manipulation than real surgical field was mandatory in order to prevent damage in the brain tissue. Therefore, this concentration of NVP was considered to be appropriate. In conclusion, NVP embalming was effective for endoscopic transnasal skull base approach in cadaver dissection, providing environment similar to the real surgical field. |
format | Online Article Text |
id | pubmed-6796061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japan Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-67960612019-10-17 Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection MARUYAMA, Keisuke YOKOI, Hidenori NAGASE, Miki YOSHIDA, Hiroki NOGUCHI, Akio MATSUMURA, George SAITO, Koichiro SHIOKAWA, Yoshiaki Neurol Med Chir (Tokyo) Original Article Formalin or formaldehyde is commonly used for cadaver fixation, which is, however, not suitable for endoscopic transnasal skull base approach because of consequent hardening of the soft tissue. Several alternatives have been reported, but each of them also has some limitations. We applied a novel fixation method using N-vinyl-2-pyrrolidone (NVP), a precursor of the water-soluble macromolecular polymer, for endoscopic transnasal skull base approach in six donated cadaver specimens. In four cadavers, elasticity of the soft tissue in the nasal cavity was almost similar to that of living tissue, and a surgical approach similar to the real surgical field was possible. However, the soft tissue was moderately stiffer than living tissue in two specimens so that surgical manipulation was hindered to some extent while NVP concentration was 10% in all the cadavers. Since the brain tissue was too soft and pliable for surgical manipulation in NVP, more careful surgical manipulation than real surgical field was mandatory in order to prevent damage in the brain tissue. Therefore, this concentration of NVP was considered to be appropriate. In conclusion, NVP embalming was effective for endoscopic transnasal skull base approach in cadaver dissection, providing environment similar to the real surgical field. The Japan Neurosurgical Society 2019-10 2019-07-04 /pmc/articles/PMC6796061/ /pubmed/31270286 http://dx.doi.org/10.2176/nmc.oa.2019-0069 Text en © 2019 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article MARUYAMA, Keisuke YOKOI, Hidenori NAGASE, Miki YOSHIDA, Hiroki NOGUCHI, Akio MATSUMURA, George SAITO, Koichiro SHIOKAWA, Yoshiaki Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title | Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title_full | Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title_fullStr | Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title_full_unstemmed | Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title_short | Usefulness of N-vinyl-2-pyrrolidone Embalming for Endoscopic Transnasal Skull Base Approach in Cadaver Dissection |
title_sort | usefulness of n-vinyl-2-pyrrolidone embalming for endoscopic transnasal skull base approach in cadaver dissection |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796061/ https://www.ncbi.nlm.nih.gov/pubmed/31270286 http://dx.doi.org/10.2176/nmc.oa.2019-0069 |
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