Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant

[Image: see text] Hepatitis C virus (HCV) is a human pathogen with high morbidity. The HCV NS3/4A protease is essential for viral replication and is one of the top three drug targets. Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screen...

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Detalles Bibliográficos
Autores principales: Meewan, Ittipat, Zhang, Xingquan, Roy, Suchismita, Ballatore, Carlo, O’Donoghue, Anthony J., Schooley, Robert T., Abagyan, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796237/
https://www.ncbi.nlm.nih.gov/pubmed/31646247
http://dx.doi.org/10.1021/acsomega.9b02491

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