Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

BACKGROUND: CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silencing and loss of function. While the prevalence of CRC differs across geographica...

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Detalles Bibliográficos
Autores principales: Advani, Shailesh Mahesh, Advani, Pragati Shailesh, Brown, Derek W., DeSantis, Stacia M., Korphaisarn, Krittiya, VonVille, Helena M., Bressler, Jan, Lopez, David S., Davis, Jennifer S., Daniel, Carrie R., Sarshekeh, Amir Mehrvarz, Braithwaite, Dejana, Swartz, Michael D., Kopetz, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796359/
https://www.ncbi.nlm.nih.gov/pubmed/31623592
http://dx.doi.org/10.1186/s12885-019-6144-9

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