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Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark
BACKGROUND: Screening mammography works better in fatty than in dense breast tissue. Computerized assessment of parenchymal texture is a non-subjective method to obtain a refined description of breast tissue, potentially valuable in addition to breast density scoring for the identification of women...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796411/ https://www.ncbi.nlm.nih.gov/pubmed/31623646 http://dx.doi.org/10.1186/s13058-019-1203-3 |
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author | von Euler-Chelpin, My Lillholm, Martin Vejborg, Ilse Nielsen, Mads Lynge, Elsebeth |
author_facet | von Euler-Chelpin, My Lillholm, Martin Vejborg, Ilse Nielsen, Mads Lynge, Elsebeth |
author_sort | von Euler-Chelpin, My |
collection | PubMed |
description | BACKGROUND: Screening mammography works better in fatty than in dense breast tissue. Computerized assessment of parenchymal texture is a non-subjective method to obtain a refined description of breast tissue, potentially valuable in addition to breast density scoring for the identification of women in need of supplementary imaging. We studied the sensitivity of screening mammography by a combination of radiologist-assessed Breast Imaging Reporting and Data System (BI-RADS) density score and computer-assessed parenchymal texture marker, mammography texture resemblance (MTR), in a population-based screening program. METHODS: Breast density was coded according to the fourth edition of the BI-RADS density code, and MTR marker was divided into quartiles from 1 to 4. Screening data were followed up for the identification of screen-detected and interval cancers. We calculated sensitivity and specificity with 95% confidence intervals (CI) by BI-RADS density score, MTR marker, and combination hereof. RESULTS: Density and texture were strongly correlated, but the combination led to the identification of subgroups with different sensitivity. Sensitivity was high, about 80%, in women with BI-RADS density score 1 and MTR markers 1 or 2. Sensitivity was low, 67%, in women with BI-RADS density score 2 and MTR marker 4. For women with BI-RADS density scores 3 and 4, the already low sensitivity was further decreased for women with MTR marker 4. Specificity was 97–99% in all subgroups. CONCLUSION: Our study showed that women with low density constituted a heterogenous group. Classifying women for extra imaging based on density only might be a too crude approach. Screening sensitivity was systematically high in women with fatty and homogenous breast tissue. |
format | Online Article Text |
id | pubmed-6796411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67964112019-10-21 Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark von Euler-Chelpin, My Lillholm, Martin Vejborg, Ilse Nielsen, Mads Lynge, Elsebeth Breast Cancer Res Research Article BACKGROUND: Screening mammography works better in fatty than in dense breast tissue. Computerized assessment of parenchymal texture is a non-subjective method to obtain a refined description of breast tissue, potentially valuable in addition to breast density scoring for the identification of women in need of supplementary imaging. We studied the sensitivity of screening mammography by a combination of radiologist-assessed Breast Imaging Reporting and Data System (BI-RADS) density score and computer-assessed parenchymal texture marker, mammography texture resemblance (MTR), in a population-based screening program. METHODS: Breast density was coded according to the fourth edition of the BI-RADS density code, and MTR marker was divided into quartiles from 1 to 4. Screening data were followed up for the identification of screen-detected and interval cancers. We calculated sensitivity and specificity with 95% confidence intervals (CI) by BI-RADS density score, MTR marker, and combination hereof. RESULTS: Density and texture were strongly correlated, but the combination led to the identification of subgroups with different sensitivity. Sensitivity was high, about 80%, in women with BI-RADS density score 1 and MTR markers 1 or 2. Sensitivity was low, 67%, in women with BI-RADS density score 2 and MTR marker 4. For women with BI-RADS density scores 3 and 4, the already low sensitivity was further decreased for women with MTR marker 4. Specificity was 97–99% in all subgroups. CONCLUSION: Our study showed that women with low density constituted a heterogenous group. Classifying women for extra imaging based on density only might be a too crude approach. Screening sensitivity was systematically high in women with fatty and homogenous breast tissue. BioMed Central 2019-10-17 2019 /pmc/articles/PMC6796411/ /pubmed/31623646 http://dx.doi.org/10.1186/s13058-019-1203-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article von Euler-Chelpin, My Lillholm, Martin Vejborg, Ilse Nielsen, Mads Lynge, Elsebeth Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title_full | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title_fullStr | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title_full_unstemmed | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title_short | Sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in Denmark |
title_sort | sensitivity of screening mammography by density and texture: a cohort study from a population-based screening program in denmark |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796411/ https://www.ncbi.nlm.nih.gov/pubmed/31623646 http://dx.doi.org/10.1186/s13058-019-1203-3 |
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