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PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

BACKGROUND: Liver cancer is the second leading causes of cancer-related death globally. Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of tumors. Therefore, it is necessary to explore the mechanisms of PYCR1 on cell growth and survival in hepatocellular carci...

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Detalles Bibliográficos
Autores principales:	Zhuang, Juhua, Song, Yanan, Ye, Ying, He, Saifei, Ma, Xing, Zhang, Miao, Ni, Jing, Wang, Jiening, Xia, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796468/ https://www.ncbi.nlm.nih.gov/pubmed/31619254 http://dx.doi.org/10.1186/s12967-019-2091-0

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