Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease

BACKGROUND: Multiple preclinical studies have highlighted AMP-activated protein kinase (AMPK) as a potential therapeutic target for autosomal dominant polycystic kidney disease (ADPKD). Both metformin and canagliflozin indirectly activate AMPK by inhibiting mitochondrial function, while salsalate is...

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Detalles Bibliográficos
Autores principales: Leonhard, Wouter N., Song, Xuewen, Kanhai, Anish A., Iliuta, Ioan-Andrei, Bozovic, Andrea, Steinberg, Gregory R., Peters, Dorien J.M., Pei, York
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796518/
https://www.ncbi.nlm.nih.gov/pubmed/31473186
http://dx.doi.org/10.1016/j.ebiom.2019.08.041

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