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Antibody-dependent cellular cytotoxicity targeting CD4-inducible epitopes predicts mortality in HIV-infected infants

BACKGROUND: Antibody-dependent cellular cytotoxicity (ADCC) has been associated with improved infant outcome in mother-to-child transmission (MTCT) of HIV-1. Epitopes of these ADCC-mediating antibodies remain unidentified. CD4-inducible (CD4i) epitopes on gp120 are common ADCC targets in natural inf...

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Detalles Bibliográficos
Autores principales:	Naiman, Nicole E., Slyker, Jennifer, Richardson, Barbra A., John-Stewart, Grace, Nduati, Ruth, Overbaugh, Julie M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796543/ https://www.ncbi.nlm.nih.gov/pubmed/31501077 http://dx.doi.org/10.1016/j.ebiom.2019.08.072

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