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Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer

BACKGROUND: Spleen tyrosine kinase (SYK) is frequently upregulated in recurrent ovarian carcinomas, for which effective therapy is urgently needed. SYK phosphorylates several substrates, but their translational implications remain unclear. Here, we show that SYK interacts with EGFR and ERBB2, and di...

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Detalles Bibliográficos
Autores principales:	Yu, Yu, Suryo Rahmanto, Yohan, Shen, Yao-An, Ardighieri, Laura, Davidson, Ben, Gaillard, Stephanie, Ayhan, Ayse, Shi, Xu, Xuan, Jianhua, Wang, Tian-Li, Shih, Ie-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796592/ https://www.ncbi.nlm.nih.gov/pubmed/31492560 http://dx.doi.org/10.1016/j.ebiom.2019.08.055

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