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Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compul...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Psiquiatria
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796817/ https://www.ncbi.nlm.nih.gov/pubmed/31166547 http://dx.doi.org/10.1590/1516-4446-2019-0344 |
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author | Marques, Rodrigo C. Vieira, Larissa Marques, Déborah Cantilino, Amaury |
author_facet | Marques, Rodrigo C. Vieira, Larissa Marques, Déborah Cantilino, Amaury |
author_sort | Marques, Rodrigo C. |
collection | PubMed |
description | OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compulsive disorder (OCD), and anxiety disorders. Repetitive transcranial magnetic stimulation (rTMS) studies targeting the mPFC indicate that it may be a useful therapeutic resource in psychiatry due to its selective modulation of this area and connected regions. METHODS: This review examines six mPFC rTMS trials selected from 697 initial search results. We discuss the main results, technical and methodological details, safety, tolerability, and localization strategies. RESULTS: Six different protocols were identified, including inhibitory (1 Hz) and excitatory (5, 10, and 20 Hz) frequencies applied therapeutically to patient populations diagnosed with major depressive disorder, OCD, autistic spectrum disorder, SUD, specific phobia, and post-traumatic stress disorder (PTSD). In the OCD and acrophobia trials, rTMS significantly reduced symptoms compared to placebo. CONCLUSION: These protocols were considered safe and add interesting new evidence to the growing body of mPFC rTMS literature. However, the small number and low methodological quality of the studies indicate the need for further research. |
format | Online Article Text |
id | pubmed-6796817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Associação Brasileira de Psiquiatria |
record_format | MEDLINE/PubMed |
spelling | pubmed-67968172019-10-25 Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review Marques, Rodrigo C. Vieira, Larissa Marques, Déborah Cantilino, Amaury Braz J Psychiatry Review Article OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compulsive disorder (OCD), and anxiety disorders. Repetitive transcranial magnetic stimulation (rTMS) studies targeting the mPFC indicate that it may be a useful therapeutic resource in psychiatry due to its selective modulation of this area and connected regions. METHODS: This review examines six mPFC rTMS trials selected from 697 initial search results. We discuss the main results, technical and methodological details, safety, tolerability, and localization strategies. RESULTS: Six different protocols were identified, including inhibitory (1 Hz) and excitatory (5, 10, and 20 Hz) frequencies applied therapeutically to patient populations diagnosed with major depressive disorder, OCD, autistic spectrum disorder, SUD, specific phobia, and post-traumatic stress disorder (PTSD). In the OCD and acrophobia trials, rTMS significantly reduced symptoms compared to placebo. CONCLUSION: These protocols were considered safe and add interesting new evidence to the growing body of mPFC rTMS literature. However, the small number and low methodological quality of the studies indicate the need for further research. Associação Brasileira de Psiquiatria 2019-05-30 /pmc/articles/PMC6796817/ /pubmed/31166547 http://dx.doi.org/10.1590/1516-4446-2019-0344 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Marques, Rodrigo C. Vieira, Larissa Marques, Déborah Cantilino, Amaury Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title | Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title_full | Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title_fullStr | Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title_full_unstemmed | Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title_short | Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
title_sort | transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796817/ https://www.ncbi.nlm.nih.gov/pubmed/31166547 http://dx.doi.org/10.1590/1516-4446-2019-0344 |
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