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Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review

OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compul...

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Autores principales: Marques, Rodrigo C., Vieira, Larissa, Marques, Déborah, Cantilino, Amaury
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796817/
https://www.ncbi.nlm.nih.gov/pubmed/31166547
http://dx.doi.org/10.1590/1516-4446-2019-0344
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author Marques, Rodrigo C.
Vieira, Larissa
Marques, Déborah
Cantilino, Amaury
author_facet Marques, Rodrigo C.
Vieira, Larissa
Marques, Déborah
Cantilino, Amaury
author_sort Marques, Rodrigo C.
collection PubMed
description OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compulsive disorder (OCD), and anxiety disorders. Repetitive transcranial magnetic stimulation (rTMS) studies targeting the mPFC indicate that it may be a useful therapeutic resource in psychiatry due to its selective modulation of this area and connected regions. METHODS: This review examines six mPFC rTMS trials selected from 697 initial search results. We discuss the main results, technical and methodological details, safety, tolerability, and localization strategies. RESULTS: Six different protocols were identified, including inhibitory (1 Hz) and excitatory (5, 10, and 20 Hz) frequencies applied therapeutically to patient populations diagnosed with major depressive disorder, OCD, autistic spectrum disorder, SUD, specific phobia, and post-traumatic stress disorder (PTSD). In the OCD and acrophobia trials, rTMS significantly reduced symptoms compared to placebo. CONCLUSION: These protocols were considered safe and add interesting new evidence to the growing body of mPFC rTMS literature. However, the small number and low methodological quality of the studies indicate the need for further research.
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spelling pubmed-67968172019-10-25 Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review Marques, Rodrigo C. Vieira, Larissa Marques, Déborah Cantilino, Amaury Braz J Psychiatry Review Article OBJECTIVE: The medial prefrontal cortex (mPFC) is a highly connected cortical region that acts as a hub in major large-scale brain networks. Its dysfunction is associated with a number of psychiatric disorders, such as schizophrenia, autism, depression, substance use disorder (SUD), obsessive-compulsive disorder (OCD), and anxiety disorders. Repetitive transcranial magnetic stimulation (rTMS) studies targeting the mPFC indicate that it may be a useful therapeutic resource in psychiatry due to its selective modulation of this area and connected regions. METHODS: This review examines six mPFC rTMS trials selected from 697 initial search results. We discuss the main results, technical and methodological details, safety, tolerability, and localization strategies. RESULTS: Six different protocols were identified, including inhibitory (1 Hz) and excitatory (5, 10, and 20 Hz) frequencies applied therapeutically to patient populations diagnosed with major depressive disorder, OCD, autistic spectrum disorder, SUD, specific phobia, and post-traumatic stress disorder (PTSD). In the OCD and acrophobia trials, rTMS significantly reduced symptoms compared to placebo. CONCLUSION: These protocols were considered safe and add interesting new evidence to the growing body of mPFC rTMS literature. However, the small number and low methodological quality of the studies indicate the need for further research. Associação Brasileira de Psiquiatria 2019-05-30 /pmc/articles/PMC6796817/ /pubmed/31166547 http://dx.doi.org/10.1590/1516-4446-2019-0344 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Marques, Rodrigo C.
Vieira, Larissa
Marques, Déborah
Cantilino, Amaury
Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title_full Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title_fullStr Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title_full_unstemmed Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title_short Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
title_sort transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796817/
https://www.ncbi.nlm.nih.gov/pubmed/31166547
http://dx.doi.org/10.1590/1516-4446-2019-0344
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