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Monitoring Heterogeneously Catalyzed Hydrogenation Reactions at Elevated Pressures Using In-Line Flow NMR
[Image: see text] We present a novel setup that can be used for the in-line monitoring of solid-catalyzed gas–liquid reactions. The method combines the high sensitivity and resolution of a stripline NMR detector with a microfluidic network that can withstand elevated pressures. In our setup we disso...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796828/ https://www.ncbi.nlm.nih.gov/pubmed/31508941 http://dx.doi.org/10.1021/acs.analchem.9b00895 |
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author | Tijssen, Koen C. H. van Weerdenburg, Bram J. A. Zhang, Hainan Janssen, J. W. G. Feiters, Martin C. van Bentum, P. Jan M. Kentgens, Arno P. M. |
author_facet | Tijssen, Koen C. H. van Weerdenburg, Bram J. A. Zhang, Hainan Janssen, J. W. G. Feiters, Martin C. van Bentum, P. Jan M. Kentgens, Arno P. M. |
author_sort | Tijssen, Koen C. H. |
collection | PubMed |
description | [Image: see text] We present a novel setup that can be used for the in-line monitoring of solid-catalyzed gas–liquid reactions. The method combines the high sensitivity and resolution of a stripline NMR detector with a microfluidic network that can withstand elevated pressures. In our setup we dissolve hydrogen gas in the solvent, then flow it with the added substrate through a catalyst cartridge, and finally flow the reaction mixture directly through the stripline NMR detector. The method is quantitative and can be used to determine the solubility of hydrogen gas in liquids; it allows in-line monitoring of hydrogenation reactions and can be used to determine the reaction kinetics of these reactions. In this work, as proof of concept we demonstrate the optimization of the Pd-catalyzed hydrogenation reactions of styrene, phenylacetylene, cyclohexene, and hex-5-en-2-one in a microfluidic context. |
format | Online Article Text |
id | pubmed-6796828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-67968282019-10-23 Monitoring Heterogeneously Catalyzed Hydrogenation Reactions at Elevated Pressures Using In-Line Flow NMR Tijssen, Koen C. H. van Weerdenburg, Bram J. A. Zhang, Hainan Janssen, J. W. G. Feiters, Martin C. van Bentum, P. Jan M. Kentgens, Arno P. M. Anal Chem [Image: see text] We present a novel setup that can be used for the in-line monitoring of solid-catalyzed gas–liquid reactions. The method combines the high sensitivity and resolution of a stripline NMR detector with a microfluidic network that can withstand elevated pressures. In our setup we dissolve hydrogen gas in the solvent, then flow it with the added substrate through a catalyst cartridge, and finally flow the reaction mixture directly through the stripline NMR detector. The method is quantitative and can be used to determine the solubility of hydrogen gas in liquids; it allows in-line monitoring of hydrogenation reactions and can be used to determine the reaction kinetics of these reactions. In this work, as proof of concept we demonstrate the optimization of the Pd-catalyzed hydrogenation reactions of styrene, phenylacetylene, cyclohexene, and hex-5-en-2-one in a microfluidic context. American Chemical Society 2019-09-11 2019-10-15 /pmc/articles/PMC6796828/ /pubmed/31508941 http://dx.doi.org/10.1021/acs.analchem.9b00895 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Tijssen, Koen C. H. van Weerdenburg, Bram J. A. Zhang, Hainan Janssen, J. W. G. Feiters, Martin C. van Bentum, P. Jan M. Kentgens, Arno P. M. Monitoring Heterogeneously Catalyzed Hydrogenation Reactions at Elevated Pressures Using In-Line Flow NMR |
title | Monitoring Heterogeneously Catalyzed Hydrogenation
Reactions at Elevated Pressures Using In-Line Flow NMR |
title_full | Monitoring Heterogeneously Catalyzed Hydrogenation
Reactions at Elevated Pressures Using In-Line Flow NMR |
title_fullStr | Monitoring Heterogeneously Catalyzed Hydrogenation
Reactions at Elevated Pressures Using In-Line Flow NMR |
title_full_unstemmed | Monitoring Heterogeneously Catalyzed Hydrogenation
Reactions at Elevated Pressures Using In-Line Flow NMR |
title_short | Monitoring Heterogeneously Catalyzed Hydrogenation
Reactions at Elevated Pressures Using In-Line Flow NMR |
title_sort | monitoring heterogeneously catalyzed hydrogenation
reactions at elevated pressures using in-line flow nmr |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796828/ https://www.ncbi.nlm.nih.gov/pubmed/31508941 http://dx.doi.org/10.1021/acs.analchem.9b00895 |
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