A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts

Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits...

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Detalles Bibliográficos
Autores principales: Xie, Bingqing, Sun, Da, Du, Yuanyuan, Jia, Jun, Sun, Shicheng, Xu, Jun, Liu, Yifang, Xiang, Chengang, Chen, Sitong, Xie, Huangfan, Wang, Qiming, Li, Guangya, LYU, Xuehui, Shen, Hui, Li, Shiyu, Wu, Min, Zhang, Xiaonan, Pu, Yue, Xiang, Kuanhui, Lai, Weifeng, Du, Peng, Yuan, Zhenghong, Li, Cheng, Shi, Yan, Lu, Shichun, Deng, Hongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796870/
https://www.ncbi.nlm.nih.gov/pubmed/31270412
http://dx.doi.org/10.1038/s41422-019-0196-x

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