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Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027

Clostridium difficile infection (CDI) is a leading cause of hospital-acquired diarrhea. In recent decades, the emergence of the “hypervirulent” BI/NAP1/027 strains of C. difficile significantly increased the morbidity and mortality of CDI. The pathogenesis of CDI is primarily mediated by the action...

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Detalles Bibliográficos
Autores principales:	Peng, Zeyu, Simeon, Rudo, Mitchell, Samuel B., Zhang, Junjie, Feng, Hanping, Chen, Zhilei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796971/ https://www.ncbi.nlm.nih.gov/pubmed/31578248 http://dx.doi.org/10.1128/mSphere.00596-19

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