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Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial

CONTEXT: Vitamin D(2) and vitamin D(3) have been hypothesized to exert differential effects on vitamin D metabolism. OBJECTIVE: To compare the influence of administering vitamin D(2) vs vitamin D(3) on metabolism of vitamin D(3). METHODS: We measured baseline and 4-month serum concentrations of vita...

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Autores principales: Martineau, Adrian R, Thummel, Kenneth E, Wang, Zhican, Jolliffe, David A, Boucher, Barbara J, Griffin, Simon J, Forouhi, Nita G, Hitman, Graham A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797055/
https://www.ncbi.nlm.nih.gov/pubmed/31199458
http://dx.doi.org/10.1210/jc.2019-00207
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author Martineau, Adrian R
Thummel, Kenneth E
Wang, Zhican
Jolliffe, David A
Boucher, Barbara J
Griffin, Simon J
Forouhi, Nita G
Hitman, Graham A
author_facet Martineau, Adrian R
Thummel, Kenneth E
Wang, Zhican
Jolliffe, David A
Boucher, Barbara J
Griffin, Simon J
Forouhi, Nita G
Hitman, Graham A
author_sort Martineau, Adrian R
collection PubMed
description CONTEXT: Vitamin D(2) and vitamin D(3) have been hypothesized to exert differential effects on vitamin D metabolism. OBJECTIVE: To compare the influence of administering vitamin D(2) vs vitamin D(3) on metabolism of vitamin D(3). METHODS: We measured baseline and 4-month serum concentrations of vitamin D(3,) 25-hydroxyvitamin D(3) [25(OH)D(3)], 25-hydroxyvitamin D(2), 24R,25-dihydroxyvitamin D(3) [24R,25(OH)(2)D(3)], 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)], and 4β,25-dihydroxyvitamin D(3) [4β,25(OH)(2)D(3)] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D(2) (n = 28) or vitamin D(3) (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of vitamin D(2) and vitamin D(3) on metabolism of vitamin D. Mean postsupplementation metabolite-to-parent ratios were then compared between groups. RESULTS: Vitamin D(2) was less effective than vitamin D(3) in elevating total serum 25(OH)D concentration. Vitamin D(2) suppressed mean four-month serum concentrations of 25(OH)D(3), 24R,25(OH)(2)D(3), 1α,25(OH)(2)D(3), and 4β,25(OH)(2)D(3) and mean ratios of 25(OH)D(3) to D(3) and 1α,25(OH)(2)D(3) to 25(OH)D(3), while increasing the mean ratio of 24R,25(OH)(2)D(3) to 25(OH)D(3). Vitamin D(3) increased mean four-month serum concentrations of 25(OH)D(3), 24R,25(OH)(2)D(3), 1α,25(OH)(2)D(3), and 4β,25(OH)(2)D(3) and the mean ratio of 24R,25(OH)(2)D(3) to 25(OH)D(3). Participants receiving vitamin D(2) had lower mean postsupplementation ratios of 25(OH)D(3) to vitamin D(3) and 1α,25(OH)(2)D(3) to 25(OH)D(3) than those receiving vitamin D(3). Mean postsupplementation ratios of 24R,25(OH)(2)D(3) to 25(OH)D(3) and 4β,25(OH)(2)D(3) to 25(OH)D(3) did not differ between groups. CONCLUSIONS: Bolus-dose vitamin D(2) is less effective than bolus-dose vitamin D(3) in elevating total serum 25(OH)D concentration. Administration of vitamin D(2) reduces 25-hydroxylation of vitamin D(3) and 1-α hydroxylation of 25(OH)D(3), while increasing 24R-hydroxylation of 25(OH)D(3).
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spelling pubmed-67970552019-11-07 Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial Martineau, Adrian R Thummel, Kenneth E Wang, Zhican Jolliffe, David A Boucher, Barbara J Griffin, Simon J Forouhi, Nita G Hitman, Graham A J Clin Endocrinol Metab Clinical Research Articles CONTEXT: Vitamin D(2) and vitamin D(3) have been hypothesized to exert differential effects on vitamin D metabolism. OBJECTIVE: To compare the influence of administering vitamin D(2) vs vitamin D(3) on metabolism of vitamin D(3). METHODS: We measured baseline and 4-month serum concentrations of vitamin D(3,) 25-hydroxyvitamin D(3) [25(OH)D(3)], 25-hydroxyvitamin D(2), 24R,25-dihydroxyvitamin D(3) [24R,25(OH)(2)D(3)], 1α,25-dihydroxyvitamin D(3) [1α,25(OH)(2)D(3)], and 4β,25-dihydroxyvitamin D(3) [4β,25(OH)(2)D(3)] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D(2) (n = 28) or vitamin D(3) (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of vitamin D(2) and vitamin D(3) on metabolism of vitamin D. Mean postsupplementation metabolite-to-parent ratios were then compared between groups. RESULTS: Vitamin D(2) was less effective than vitamin D(3) in elevating total serum 25(OH)D concentration. Vitamin D(2) suppressed mean four-month serum concentrations of 25(OH)D(3), 24R,25(OH)(2)D(3), 1α,25(OH)(2)D(3), and 4β,25(OH)(2)D(3) and mean ratios of 25(OH)D(3) to D(3) and 1α,25(OH)(2)D(3) to 25(OH)D(3), while increasing the mean ratio of 24R,25(OH)(2)D(3) to 25(OH)D(3). Vitamin D(3) increased mean four-month serum concentrations of 25(OH)D(3), 24R,25(OH)(2)D(3), 1α,25(OH)(2)D(3), and 4β,25(OH)(2)D(3) and the mean ratio of 24R,25(OH)(2)D(3) to 25(OH)D(3). Participants receiving vitamin D(2) had lower mean postsupplementation ratios of 25(OH)D(3) to vitamin D(3) and 1α,25(OH)(2)D(3) to 25(OH)D(3) than those receiving vitamin D(3). Mean postsupplementation ratios of 24R,25(OH)(2)D(3) to 25(OH)D(3) and 4β,25(OH)(2)D(3) to 25(OH)D(3) did not differ between groups. CONCLUSIONS: Bolus-dose vitamin D(2) is less effective than bolus-dose vitamin D(3) in elevating total serum 25(OH)D concentration. Administration of vitamin D(2) reduces 25-hydroxylation of vitamin D(3) and 1-α hydroxylation of 25(OH)D(3), while increasing 24R-hydroxylation of 25(OH)D(3). Endocrine Society 2019-06-14 /pmc/articles/PMC6797055/ /pubmed/31199458 http://dx.doi.org/10.1210/jc.2019-00207 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by/4.0/ This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
spellingShingle Clinical Research Articles
Martineau, Adrian R
Thummel, Kenneth E
Wang, Zhican
Jolliffe, David A
Boucher, Barbara J
Griffin, Simon J
Forouhi, Nita G
Hitman, Graham A
Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title_full Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title_fullStr Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title_full_unstemmed Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title_short Differential Effects of Oral Boluses of Vitamin D(2) vs Vitamin D(3) on Vitamin D Metabolism: A Randomized Controlled Trial
title_sort differential effects of oral boluses of vitamin d(2) vs vitamin d(3) on vitamin d metabolism: a randomized controlled trial
topic Clinical Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797055/
https://www.ncbi.nlm.nih.gov/pubmed/31199458
http://dx.doi.org/10.1210/jc.2019-00207
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