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Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons

BACKGROUND: Interatrial blocks are considered a new important risk factor for atrial fibrillation and cerebrovascular events. Their prevalence and clinical implications have been reported in general population and several subgroups of patients but no data from HIV-infected populations, with a non-ne...

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Autores principales: Fanjul, Francisco, Campins, Antoni, Asensio, Javier, Sampériz, Gloria, Yañez, Aina, Romaguera, Dora, Fiol, Miquel, Riera, Melchor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797089/
https://www.ncbi.nlm.nih.gov/pubmed/31622385
http://dx.doi.org/10.1371/journal.pone.0223777
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author Fanjul, Francisco
Campins, Antoni
Asensio, Javier
Sampériz, Gloria
Yañez, Aina
Romaguera, Dora
Fiol, Miquel
Riera, Melchor
author_facet Fanjul, Francisco
Campins, Antoni
Asensio, Javier
Sampériz, Gloria
Yañez, Aina
Romaguera, Dora
Fiol, Miquel
Riera, Melchor
author_sort Fanjul, Francisco
collection PubMed
description BACKGROUND: Interatrial blocks are considered a new important risk factor for atrial fibrillation and cerebrovascular events. Their prevalence and clinical implications have been reported in general population and several subgroups of patients but no data from HIV-infected populations, with a non-negligible prevalence of atrial fibrillation, has been previously reported. METHODS: We conducted a cross-sectional study in a previously enrolled cohort of randomly selected middle-aged HIV-infected patients who attended our hospital and were clinically stable. Patients underwent both a 12-lead rest electrocardiogram and clinical questionnaires while epidemiological, clinical and HIV-related variables were obtained from electronic medical records and interviews with the patients. Electrocardiograms were then analyzed and codified using a standardized form by two trained members of the research team who were blinded to clinical variables. RESULTS: We obtained electrocardiograms from 204 patients with a mean age of 55.22 years, 39 patients (19.12%) presented an interatrial block, 9 (4.41%) advanced and 30 (14.71%) partial. Patients with interatrial block had a lower nadir lymphocyte CD4 count (124 vs 198 cells, p = 0.02) while advanced interatrial blocks were associated to older age (62.16 vs. 54.95 years, p = 0.046) and hypertension (77.8% vs. 32.3%, p = 0.009). We did not find differences regarding baseline CD4 lymphocyte count or CD4/CD8 lymphocyte ratio. Clinical variables and functional capacity among patients with or without interatrial block were similar. CONCLUSIONS: In a cohort of clinically stable HIV infected patients the prevalence of interatrial blocks, specially advanced, is high and associated to previously known factors (age, hypertension) and novel ones (nadir CD4 lymphocyte count).
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spelling pubmed-67970892019-10-20 Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons Fanjul, Francisco Campins, Antoni Asensio, Javier Sampériz, Gloria Yañez, Aina Romaguera, Dora Fiol, Miquel Riera, Melchor PLoS One Research Article BACKGROUND: Interatrial blocks are considered a new important risk factor for atrial fibrillation and cerebrovascular events. Their prevalence and clinical implications have been reported in general population and several subgroups of patients but no data from HIV-infected populations, with a non-negligible prevalence of atrial fibrillation, has been previously reported. METHODS: We conducted a cross-sectional study in a previously enrolled cohort of randomly selected middle-aged HIV-infected patients who attended our hospital and were clinically stable. Patients underwent both a 12-lead rest electrocardiogram and clinical questionnaires while epidemiological, clinical and HIV-related variables were obtained from electronic medical records and interviews with the patients. Electrocardiograms were then analyzed and codified using a standardized form by two trained members of the research team who were blinded to clinical variables. RESULTS: We obtained electrocardiograms from 204 patients with a mean age of 55.22 years, 39 patients (19.12%) presented an interatrial block, 9 (4.41%) advanced and 30 (14.71%) partial. Patients with interatrial block had a lower nadir lymphocyte CD4 count (124 vs 198 cells, p = 0.02) while advanced interatrial blocks were associated to older age (62.16 vs. 54.95 years, p = 0.046) and hypertension (77.8% vs. 32.3%, p = 0.009). We did not find differences regarding baseline CD4 lymphocyte count or CD4/CD8 lymphocyte ratio. Clinical variables and functional capacity among patients with or without interatrial block were similar. CONCLUSIONS: In a cohort of clinically stable HIV infected patients the prevalence of interatrial blocks, specially advanced, is high and associated to previously known factors (age, hypertension) and novel ones (nadir CD4 lymphocyte count). Public Library of Science 2019-10-17 /pmc/articles/PMC6797089/ /pubmed/31622385 http://dx.doi.org/10.1371/journal.pone.0223777 Text en © 2019 Fanjul et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fanjul, Francisco
Campins, Antoni
Asensio, Javier
Sampériz, Gloria
Yañez, Aina
Romaguera, Dora
Fiol, Miquel
Riera, Melchor
Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title_full Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title_fullStr Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title_full_unstemmed Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title_short Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
title_sort interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797089/
https://www.ncbi.nlm.nih.gov/pubmed/31622385
http://dx.doi.org/10.1371/journal.pone.0223777
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