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Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations

RATIONALE: Shorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced r...

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Autores principales: Wan, Emily S., Goldstein, Rebekah L., Fan, Vincent S., Nguyen, Huong Q., Hart, Jaime E., Garshick, Eric, Orr, Esther H., DeVivo, Immaculata, Moy, Marilyn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797105/
https://www.ncbi.nlm.nih.gov/pubmed/31622416
http://dx.doi.org/10.1371/journal.pone.0223891
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author Wan, Emily S.
Goldstein, Rebekah L.
Fan, Vincent S.
Nguyen, Huong Q.
Hart, Jaime E.
Garshick, Eric
Orr, Esther H.
DeVivo, Immaculata
Moy, Marilyn L.
author_facet Wan, Emily S.
Goldstein, Rebekah L.
Fan, Vincent S.
Nguyen, Huong Q.
Hart, Jaime E.
Garshick, Eric
Orr, Esther H.
DeVivo, Immaculata
Moy, Marilyn L.
author_sort Wan, Emily S.
collection PubMed
description RATIONALE: Shorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced risk for AEs and death. However, the relationships between LTL and physical activity, exercise capacity, and AEs in COPD are unknown. METHODS: Data from 3 COPD cohorts were examined: Cohort 1 (n = 112, physical activity intervention trial), Cohorts 2 and 3 (n = 182 and 294, respectively, separate observational studies). Subjects completed a 6-minute walk test (6MWT) and provided blood for LTL assessment using real-time PCR. Physical activity was measured as average daily step count using an accelerometer or pedometer. Number of self-reported AEs was available for 1) the year prior to enrollment (Cohorts 1 and 3) and 2) prospectively after enrollment (all cohorts). Multivariate models examined associations between LTL and average daily step count, 6MWT distance, and AEs. RESULTS: A significant association between longer LTL and increased 6MWT distance was observed in the three combined cohorts (β = 3x10(-5), p = 0.045). No association between LTL and average daily step count was observed. Shorter LTL was associated with an increased number of AEs in the year prior to enrollment (Cohorts 1 and 3 combined, β = -1.93, p = 0.04) and with prospective AEs (Cohort 3, β = -1.3388, p = 0.0003). CONCLUSIONS: Among COPD patients, increased LTL is associated with higher exercise capacity, but not physical activity. Shorter LTL was associated with AEs in a subgroup of cohorts.
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spelling pubmed-67971052019-10-20 Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations Wan, Emily S. Goldstein, Rebekah L. Fan, Vincent S. Nguyen, Huong Q. Hart, Jaime E. Garshick, Eric Orr, Esther H. DeVivo, Immaculata Moy, Marilyn L. PLoS One Research Article RATIONALE: Shorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced risk for AEs and death. However, the relationships between LTL and physical activity, exercise capacity, and AEs in COPD are unknown. METHODS: Data from 3 COPD cohorts were examined: Cohort 1 (n = 112, physical activity intervention trial), Cohorts 2 and 3 (n = 182 and 294, respectively, separate observational studies). Subjects completed a 6-minute walk test (6MWT) and provided blood for LTL assessment using real-time PCR. Physical activity was measured as average daily step count using an accelerometer or pedometer. Number of self-reported AEs was available for 1) the year prior to enrollment (Cohorts 1 and 3) and 2) prospectively after enrollment (all cohorts). Multivariate models examined associations between LTL and average daily step count, 6MWT distance, and AEs. RESULTS: A significant association between longer LTL and increased 6MWT distance was observed in the three combined cohorts (β = 3x10(-5), p = 0.045). No association between LTL and average daily step count was observed. Shorter LTL was associated with an increased number of AEs in the year prior to enrollment (Cohorts 1 and 3 combined, β = -1.93, p = 0.04) and with prospective AEs (Cohort 3, β = -1.3388, p = 0.0003). CONCLUSIONS: Among COPD patients, increased LTL is associated with higher exercise capacity, but not physical activity. Shorter LTL was associated with AEs in a subgroup of cohorts. Public Library of Science 2019-10-17 /pmc/articles/PMC6797105/ /pubmed/31622416 http://dx.doi.org/10.1371/journal.pone.0223891 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Wan, Emily S.
Goldstein, Rebekah L.
Fan, Vincent S.
Nguyen, Huong Q.
Hart, Jaime E.
Garshick, Eric
Orr, Esther H.
DeVivo, Immaculata
Moy, Marilyn L.
Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title_full Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title_fullStr Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title_full_unstemmed Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title_short Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
title_sort telomere length in copd: relationships with physical activity, exercise capacity, and acute exacerbations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797105/
https://www.ncbi.nlm.nih.gov/pubmed/31622416
http://dx.doi.org/10.1371/journal.pone.0223891
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