TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo

Engineering T-cells to express receptors specific for antigens present on tumour tissue is proving a highly effective treatment for some leukaemias. However, extending this to solid tumours requires antigens that can be safely and effectively targeted. TEM8, a marker overexpressed on the vasculature...

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Detalles Bibliográficos
Autores principales: Petrovic, Kristina, Robinson, Joseph, Whitworth, Katharine, Jinks, Elizabeth, Shaaban, Abeer, Lee, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797195/
https://www.ncbi.nlm.nih.gov/pubmed/31622431
http://dx.doi.org/10.1371/journal.pone.0224015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797195/
https://www.ncbi.nlm.nih.gov/pubmed/31622431
http://dx.doi.org/10.1371/journal.pone.0224015

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