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Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysf...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797261/ https://www.ncbi.nlm.nih.gov/pubmed/31622366 http://dx.doi.org/10.1371/journal.pone.0223308 |
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author | Bouton, Tara C. de Vos, Margaretha Ragan, Elizabeth J. White, Laura F. Van Zyl, Leonie Theron, Danie Horsburgh, C. Robert Warren, Robin M. Jacobson, Karen R. |
author_facet | Bouton, Tara C. de Vos, Margaretha Ragan, Elizabeth J. White, Laura F. Van Zyl, Leonie Theron, Danie Horsburgh, C. Robert Warren, Robin M. Jacobson, Karen R. |
author_sort | Bouton, Tara C. |
collection | PubMed |
description | South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance. |
format | Online Article Text |
id | pubmed-6797261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67972612019-10-25 Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis Bouton, Tara C. de Vos, Margaretha Ragan, Elizabeth J. White, Laura F. Van Zyl, Leonie Theron, Danie Horsburgh, C. Robert Warren, Robin M. Jacobson, Karen R. PLoS One Research Article South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance. Public Library of Science 2019-10-17 /pmc/articles/PMC6797261/ /pubmed/31622366 http://dx.doi.org/10.1371/journal.pone.0223308 Text en © 2019 Bouton et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bouton, Tara C. de Vos, Margaretha Ragan, Elizabeth J. White, Laura F. Van Zyl, Leonie Theron, Danie Horsburgh, C. Robert Warren, Robin M. Jacobson, Karen R. Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title | Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title_full | Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title_fullStr | Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title_full_unstemmed | Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title_short | Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis |
title_sort | switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in south africa: a retrospective cohort analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797261/ https://www.ncbi.nlm.nih.gov/pubmed/31622366 http://dx.doi.org/10.1371/journal.pone.0223308 |
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