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Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis

South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysf...

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Autores principales: Bouton, Tara C., de Vos, Margaretha, Ragan, Elizabeth J., White, Laura F., Van Zyl, Leonie, Theron, Danie, Horsburgh, C. Robert, Warren, Robin M., Jacobson, Karen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797261/
https://www.ncbi.nlm.nih.gov/pubmed/31622366
http://dx.doi.org/10.1371/journal.pone.0223308
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author Bouton, Tara C.
de Vos, Margaretha
Ragan, Elizabeth J.
White, Laura F.
Van Zyl, Leonie
Theron, Danie
Horsburgh, C. Robert
Warren, Robin M.
Jacobson, Karen R.
author_facet Bouton, Tara C.
de Vos, Margaretha
Ragan, Elizabeth J.
White, Laura F.
Van Zyl, Leonie
Theron, Danie
Horsburgh, C. Robert
Warren, Robin M.
Jacobson, Karen R.
author_sort Bouton, Tara C.
collection PubMed
description South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.
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spelling pubmed-67972612019-10-25 Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis Bouton, Tara C. de Vos, Margaretha Ragan, Elizabeth J. White, Laura F. Van Zyl, Leonie Theron, Danie Horsburgh, C. Robert Warren, Robin M. Jacobson, Karen R. PLoS One Research Article South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance. Public Library of Science 2019-10-17 /pmc/articles/PMC6797261/ /pubmed/31622366 http://dx.doi.org/10.1371/journal.pone.0223308 Text en © 2019 Bouton et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bouton, Tara C.
de Vos, Margaretha
Ragan, Elizabeth J.
White, Laura F.
Van Zyl, Leonie
Theron, Danie
Horsburgh, C. Robert
Warren, Robin M.
Jacobson, Karen R.
Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title_full Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title_fullStr Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title_full_unstemmed Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title_short Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
title_sort switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in south africa: a retrospective cohort analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797261/
https://www.ncbi.nlm.nih.gov/pubmed/31622366
http://dx.doi.org/10.1371/journal.pone.0223308
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