Establishing Renal Proximal Tubule Epithelial-Derived Cell Lines Expressing Human Telomerase Reverse Transcriptase for Studying BK Polyomavirus

We previously established an infection model for BK polyomavirus (BKPyV) in primary human renal proximal tubule epithelial (RPTE) cells. Use of these cells is limited by their inability to be passaged extensively. Here, we describe RPTE cells immortalized with human telomerase reverse transcriptase...

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Detalles Bibliográficos
Autores principales: Zhao, Linbo, Imperiale, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Culture Collections/Mutant Libraries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797542/
https://www.ncbi.nlm.nih.gov/pubmed/31624153
http://dx.doi.org/10.1128/MRA.01129-19
Descripción
Sumario:We previously established an infection model for BK polyomavirus (BKPyV) in primary human renal proximal tubule epithelial (RPTE) cells. Use of these cells is limited by their inability to be passaged extensively. Here, we describe RPTE cells immortalized with human telomerase reverse transcriptase (hTERT), which can serve as a model system for acute or persistent BKPyV infection.

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