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Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction

Recent literature on cortical auditory evoked potentials has focused on correlations with hearing performance with the aim to develop an objective clinical tool. However, cortical responses depend on the type of stimulus and choice of stimulus parameters. This study investigates cortical auditory ev...

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Autores principales: Vonck, Bernard M.D., Lammers, Marc J.W., van der Waals, Marjolijn, van Zanten, Gijsbert A., Versnel, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797694/
https://www.ncbi.nlm.nih.gov/pubmed/31168759
http://dx.doi.org/10.1007/s10162-019-00726-2
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author Vonck, Bernard M.D.
Lammers, Marc J.W.
van der Waals, Marjolijn
van Zanten, Gijsbert A.
Versnel, Huib
author_facet Vonck, Bernard M.D.
Lammers, Marc J.W.
van der Waals, Marjolijn
van Zanten, Gijsbert A.
Versnel, Huib
author_sort Vonck, Bernard M.D.
collection PubMed
description Recent literature on cortical auditory evoked potentials has focused on correlations with hearing performance with the aim to develop an objective clinical tool. However, cortical responses depend on the type of stimulus and choice of stimulus parameters. This study investigates cortical auditory evoked potentials to sound changes, so-called acoustic change complexes (ACC), and the effects of varying three stimulus parameters. In twelve normal-hearing subjects, ACC waveforms were evoked by presenting frequency changes with varying magnitude, rate, and direction. The N1 amplitude and latency were strongly affected by magnitude, which is known from the literature. Importantly, both of these N1 variables were also significantly affected by both rate and direction of the frequency change. Larger and earlier N1 peaks were evoked by increasing the magnitude and rate of the frequency change and with downward rather than upward direction of the frequency change. The P2 amplitude increased with magnitude and depended, to a lesser extent, on rate of the frequency change while direction had no effect on this peak. The N1–P2 interval was not affected by any of the stimulus parameters. In conclusion, the ACC is most strongly affected by magnitude and also substantially by rate and direction of the change. These stimulus dependencies should be considered in choosing stimuli for ACCs as objective clinical measure of hearing performance.
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spelling pubmed-67976942019-10-25 Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction Vonck, Bernard M.D. Lammers, Marc J.W. van der Waals, Marjolijn van Zanten, Gijsbert A. Versnel, Huib J Assoc Res Otolaryngol Research Article Recent literature on cortical auditory evoked potentials has focused on correlations with hearing performance with the aim to develop an objective clinical tool. However, cortical responses depend on the type of stimulus and choice of stimulus parameters. This study investigates cortical auditory evoked potentials to sound changes, so-called acoustic change complexes (ACC), and the effects of varying three stimulus parameters. In twelve normal-hearing subjects, ACC waveforms were evoked by presenting frequency changes with varying magnitude, rate, and direction. The N1 amplitude and latency were strongly affected by magnitude, which is known from the literature. Importantly, both of these N1 variables were also significantly affected by both rate and direction of the frequency change. Larger and earlier N1 peaks were evoked by increasing the magnitude and rate of the frequency change and with downward rather than upward direction of the frequency change. The P2 amplitude increased with magnitude and depended, to a lesser extent, on rate of the frequency change while direction had no effect on this peak. The N1–P2 interval was not affected by any of the stimulus parameters. In conclusion, the ACC is most strongly affected by magnitude and also substantially by rate and direction of the change. These stimulus dependencies should be considered in choosing stimuli for ACCs as objective clinical measure of hearing performance. Springer US 2019-06-05 2019-10 /pmc/articles/PMC6797694/ /pubmed/31168759 http://dx.doi.org/10.1007/s10162-019-00726-2 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Vonck, Bernard M.D.
Lammers, Marc J.W.
van der Waals, Marjolijn
van Zanten, Gijsbert A.
Versnel, Huib
Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title_full Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title_fullStr Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title_full_unstemmed Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title_short Cortical Auditory Evoked Potentials in Response to Frequency Changes with Varied Magnitude, Rate, and Direction
title_sort cortical auditory evoked potentials in response to frequency changes with varied magnitude, rate, and direction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797694/
https://www.ncbi.nlm.nih.gov/pubmed/31168759
http://dx.doi.org/10.1007/s10162-019-00726-2
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