Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10(−4), errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

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Detalles Bibliográficos
Autores principales: Shcherbakov, Dmitri, Teo, Youjin, Boukari, Heithem, Cortes-Sanchon, Adrian, Mantovani, Matilde, Osinnii, Ivan, Moore, James, Juskeviciene, Reda, Brilkova, Margarita, Duscha, Stefan, Kumar, Harshitha Santhosh, Laczko, Endre, Rehrauer, Hubert, Westhof, Eric, Akbergenov, Rashid, Böttger, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797716/
https://www.ncbi.nlm.nih.gov/pubmed/31637312
http://dx.doi.org/10.1038/s42003-019-0626-9

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