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SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG

Speckle-type POZ domain protein (SPOP), an adaptor in the E3 ubiquitin ligase complex, recognizes substrates and promotes protein degradation via the ubiquitin-proteasome system. It appears to help regulate progression of several cancers, and we show here that it acts as a tumor suppressor in pancre...

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Detalles Bibliográficos
Autores principales:	Tan, Peng, Xu, Yunke, Du, Yichao, Wu, Lile, Guo, Bing, Huang, Shiyao, Zhu, Jinhui, Li, Bo, Lin, Fujun, Yao, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797744/ https://www.ncbi.nlm.nih.gov/pubmed/31624231 http://dx.doi.org/10.1038/s41419-019-2017-z

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