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Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty
The subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus-response rule that must be learned. Following cho...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797780/ https://www.ncbi.nlm.nih.gov/pubmed/31624264 http://dx.doi.org/10.1038/s41467-019-12725-1 |
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author | Stolyarova, A. Rakhshan, M. Hart, E. E. O’Dell, T. J. Peters, M. A. K. Lau, H. Soltani, A. Izquierdo, A. |
author_facet | Stolyarova, A. Rakhshan, M. Hart, E. E. O’Dell, T. J. Peters, M. A. K. Lau, H. Soltani, A. Izquierdo, A. |
author_sort | Stolyarova, A. |
collection | PubMed |
description | The subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus-response rule that must be learned. Following choice, rats could wait a self-timed delay for reward or initiate a new trial. Waiting times increase with discrimination accuracy, demonstrating that this measure can be used as a proxy for confidence. Chemogenetic silencing of BLA shortens waiting times overall whereas ACC inhibition renders waiting times insensitive to confidence-modulating attributes of visual stimuli, suggesting contribution of ACC but not BLA to confidence computations. Subsequent reversal learning is enhanced by confidence. Both ACC and BLA inhibition block this enhancement but via differential adjustments in learning strategies and consistent use of learned rules. Altogether, we demonstrate dissociable roles for ACC and BLA in transmitting confidence and learning under uncertainty. |
format | Online Article Text |
id | pubmed-6797780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67977802019-10-21 Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty Stolyarova, A. Rakhshan, M. Hart, E. E. O’Dell, T. J. Peters, M. A. K. Lau, H. Soltani, A. Izquierdo, A. Nat Commun Article The subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus-response rule that must be learned. Following choice, rats could wait a self-timed delay for reward or initiate a new trial. Waiting times increase with discrimination accuracy, demonstrating that this measure can be used as a proxy for confidence. Chemogenetic silencing of BLA shortens waiting times overall whereas ACC inhibition renders waiting times insensitive to confidence-modulating attributes of visual stimuli, suggesting contribution of ACC but not BLA to confidence computations. Subsequent reversal learning is enhanced by confidence. Both ACC and BLA inhibition block this enhancement but via differential adjustments in learning strategies and consistent use of learned rules. Altogether, we demonstrate dissociable roles for ACC and BLA in transmitting confidence and learning under uncertainty. Nature Publishing Group UK 2019-10-17 /pmc/articles/PMC6797780/ /pubmed/31624264 http://dx.doi.org/10.1038/s41467-019-12725-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Stolyarova, A. Rakhshan, M. Hart, E. E. O’Dell, T. J. Peters, M. A. K. Lau, H. Soltani, A. Izquierdo, A. Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title | Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title_full | Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title_fullStr | Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title_full_unstemmed | Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title_short | Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
title_sort | contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797780/ https://www.ncbi.nlm.nih.gov/pubmed/31624264 http://dx.doi.org/10.1038/s41467-019-12725-1 |
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