Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells

NK cell adoptive therapy is a promising cancer therapeutic approach, but there are significant challenges that limiting its feasibility and clinical efficacy. One difficulty is the paucity of clinical grade manufacturing platforms to support the large scale expansion of highly active NK cells. We cr...

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Detalles Bibliográficos
Autores principales: Ojo, Evelyn O., Sharma, Ashish Arunkumar, Liu, Ruifu, Moreton, Stephen, Checkley-Luttge, Mary-Ann, Gupta, Kalpana, Lee, Grace, Lee, Dean A., Otegbeye, Folashade, Sekaly, Rafick-Pierre, de Lima, Marcos, Wald, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797802/
https://www.ncbi.nlm.nih.gov/pubmed/31624330
http://dx.doi.org/10.1038/s41598-019-51287-6

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