Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy

MYCN-amplified (MNA) neuroblastoma is an aggressive neural crest-derived pediatric cancer. However, MYCN is indispensable for development and transcriptionally regulates extensive network of genes. Integrating anti-MYCN ChIP-seq and gene expression profiles of neuroblastoma patients revealed the met...

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Detalles Bibliográficos
Autores principales: Cheung, Chantal Hoi Yin, Hsu, Chia-Lang, Tsuei, Chao-Yin, Kuo, Tzu-Ting, Huang, Chen-Tsung, Hsu, Wen-Ming, Chung, Yun-Hsien, Wu, Hsin-Yi, Hsu, Cheng-Chih, Huang, Hsuan-Cheng, Juan, Hsueh-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797810/
https://www.ncbi.nlm.nih.gov/pubmed/31624245
http://dx.doi.org/10.1038/s41419-019-2033-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797810/
https://www.ncbi.nlm.nih.gov/pubmed/31624245
http://dx.doi.org/10.1038/s41419-019-2033-z

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