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Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment

Multiscale computational models of the heart are being extensively investigated for improved assessment of drug-induced torsades de pointes (TdP) risk, a fatal side effect of many drugs. Model-derived metrics such as action potential duration and net charge carried by ionic currents (qNet) have been...

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Detalles Bibliográficos
Autores principales:	Parikh, Jaimit, Di Achille, Paolo, Kozloski, James, Gurev, Viatcheslav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797832/ https://www.ncbi.nlm.nih.gov/pubmed/31680938 http://dx.doi.org/10.3389/fphar.2019.01054

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