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The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience

INTRODUCTION: Influenza is a matter of serious concern for clinicians, in both outpatient and in-hospital settings. Worldwide, the 2017-18 epidemic proved to be the most severe since 2003-04. We report a real-world experience regarding the management of patients with influenza admitted to a large te...

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Autores principales: BASSETTI, M., PEGHIN, M., GALLO, T., PIPAN, C., D’AGARO, P., SARTOR, A., BOVE, T., COCCONI, R., GRAZIANO, E., CASTALDO, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini editore srl 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797893/
https://www.ncbi.nlm.nih.gov/pubmed/31650049
http://dx.doi.org/10.15167/2421-4248/jpmh2019.60.3.1314
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author BASSETTI, M.
PEGHIN, M.
GALLO, T.
PIPAN, C.
D’AGARO, P.
SARTOR, A.
BOVE, T.
COCCONI, R.
GRAZIANO, E.
CASTALDO, N.
author_facet BASSETTI, M.
PEGHIN, M.
GALLO, T.
PIPAN, C.
D’AGARO, P.
SARTOR, A.
BOVE, T.
COCCONI, R.
GRAZIANO, E.
CASTALDO, N.
author_sort BASSETTI, M.
collection PubMed
description INTRODUCTION: Influenza is a matter of serious concern for clinicians, in both outpatient and in-hospital settings. Worldwide, the 2017-18 epidemic proved to be the most severe since 2003-04. We report a real-world experience regarding the management of patients with influenza admitted to a large teaching hospital in the Friuli Venezia Giulia region during the 2017-2018 influenza season. We also provide a practical guide for the management of hospitalized influenza patients. METHODS: A retrospective observational analysis was conducted among all influenza patients requiring admission to our center during the 2017-18 season. RESULTS: Overall, 29 patients were admitted to the University Hospital of Udine during the 2017-18 season with a diagnosis of influenza. B virus was responsible for the majority of cases. More than 65.5% of the subjects presented with a complication. We estimated that 41.4% of the patients admitted were affected by a “severe form”. All these cases required admission to the Intensive Care Unit, with 27.6% and 10.3% needing Orotracheal Intubation and Extracorporeal Membrane Oxygenation, respectively. The fatality rate was 24.1%. Notably, only 9 subjects in our cohort had been vaccinated. Based on the experience acquired during the past season, we propose a practical guide to the management of influenza cases in everyday hospital practice. CONCLUSION: The cornerstones of the management of all hospitalized influenza patients are the rapid identification and treatment of severe forms. Timely and strict adherence to contact and respiratory precautions are also fundamental to reducing the risk of intra-hospital outbreaks. Despite improvements in antiviral therapies and supportive measures, influenza-related morbidity and mortality remain high. In our opinion, a universal vaccination program is the only safe and effective method of filling the gap.
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spelling pubmed-67978932019-10-24 The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience BASSETTI, M. PEGHIN, M. GALLO, T. PIPAN, C. D’AGARO, P. SARTOR, A. BOVE, T. COCCONI, R. GRAZIANO, E. CASTALDO, N. J Prev Med Hyg Original Article INTRODUCTION: Influenza is a matter of serious concern for clinicians, in both outpatient and in-hospital settings. Worldwide, the 2017-18 epidemic proved to be the most severe since 2003-04. We report a real-world experience regarding the management of patients with influenza admitted to a large teaching hospital in the Friuli Venezia Giulia region during the 2017-2018 influenza season. We also provide a practical guide for the management of hospitalized influenza patients. METHODS: A retrospective observational analysis was conducted among all influenza patients requiring admission to our center during the 2017-18 season. RESULTS: Overall, 29 patients were admitted to the University Hospital of Udine during the 2017-18 season with a diagnosis of influenza. B virus was responsible for the majority of cases. More than 65.5% of the subjects presented with a complication. We estimated that 41.4% of the patients admitted were affected by a “severe form”. All these cases required admission to the Intensive Care Unit, with 27.6% and 10.3% needing Orotracheal Intubation and Extracorporeal Membrane Oxygenation, respectively. The fatality rate was 24.1%. Notably, only 9 subjects in our cohort had been vaccinated. Based on the experience acquired during the past season, we propose a practical guide to the management of influenza cases in everyday hospital practice. CONCLUSION: The cornerstones of the management of all hospitalized influenza patients are the rapid identification and treatment of severe forms. Timely and strict adherence to contact and respiratory precautions are also fundamental to reducing the risk of intra-hospital outbreaks. Despite improvements in antiviral therapies and supportive measures, influenza-related morbidity and mortality remain high. In our opinion, a universal vaccination program is the only safe and effective method of filling the gap. Pacini editore srl 2019-09-30 /pmc/articles/PMC6797893/ /pubmed/31650049 http://dx.doi.org/10.15167/2421-4248/jpmh2019.60.3.1314 Text en ©2019 Pacini Editore SRL, Pisa, Italy http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Article
BASSETTI, M.
PEGHIN, M.
GALLO, T.
PIPAN, C.
D’AGARO, P.
SARTOR, A.
BOVE, T.
COCCONI, R.
GRAZIANO, E.
CASTALDO, N.
The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title_full The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title_fullStr The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title_full_unstemmed The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title_short The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience
title_sort burden of severe cases of influenza disease: the friuli venezia giulia region experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797893/
https://www.ncbi.nlm.nih.gov/pubmed/31650049
http://dx.doi.org/10.15167/2421-4248/jpmh2019.60.3.1314
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