Cargando…

Validation and Clinical Applications of a Comprehensive Next Generation Sequencing System for Molecular Characterization of Solid Cancer Tissues

Identification of somatic molecular alterations in primary and metastatic solid tumor specimens can provide critical information regarding tumor biology and its heterogeneity, and enables the detection of molecular markers for clinical personalized treatment assignment. However, the optimal methods...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dehghani, Mehdi, Rosenblatt, Kevin P., Li, Lei, Rakhade, Mrudula, Amato, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798036/ https://www.ncbi.nlm.nih.gov/pubmed/31681791 http://dx.doi.org/10.3389/fmolb.2019.00082

Ejemplares similares

A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples
por: Ng, Cedric Chuan-Young, et al.
Publicado: (2022)

Detection of Mosaic Variants in Mothers of MPS II Patients by Next Generation Sequencing
por: Oliveira Netto, Alice Brinckmann, et al.
Publicado: (2021)

Somatic Mutation Profiles Revealed by Next Generation Sequencing (NGS) in 39 Chinese Hepatocellular Carcinoma Patients
por: Ke, Lixin, et al.
Publicado: (2022)

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study
por: Arras, Paul, et al.
Publicado: (2023)

Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes
por: Yang, Byeongseon, et al.
Publicado: (2020)

Next-Generation Molecular Diagnostics Development by CRISPR/Cas Tool: Rapid Detection and Surveillance of Viral Disease Outbreaks
por: Srivastava, Sonal, et al.
Publicado: (2020)

Experimental Characterization of the Hepatitis B Virus Capsid Dynamics by Solid-State NMR
por: Malär, Alexander A., et al.
Publicado: (2022)

Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies
por: Prieto-Potin, Iván, et al.
Publicado: (2020)

Comprehensive Characterization of CK1δ-Mediated Tau Phosphorylation in Alzheimer’s Disease
por: Roth, Aileen, et al.
Publicado: (2022)

Comprehensive Characterization of Ageing-Relevant Subtypes Associated With Different Tumorigenesis and Tumor Microenvironment in Prostate Cancer
por: Huang, Liang, et al.
Publicado: (2022)

Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Papillary Renal Cell Carcinoma
por: Zhang, Chiyu, et al.
Publicado: (2022)

Experimental and Meta-Analytic Validation of RNA Sequencing Signatures for Predicting Status of Microsatellite Instability
por: Sorokin, Maksim, et al.
Publicado: (2021)

The Brazilian Rare Genomes Project: Validation of Whole Genome Sequencing for Rare Diseases Diagnosis
por: Coelho, Antonio Victor Campos, et al.
Publicado: (2022)

The Sequence and Three-Dimensional Structure Characterization of Snake Venom Phospholipases B
por: Ullah, Anwar, et al.
Publicado: (2020)

Technical Validation and Clinical Utility of an NGS Targeted Panel to Improve Molecular Characterization of Pediatric Acute Leukemia
por: Vicente-Garcés, Clara, et al.
Publicado: (2022)

De novo Assembly and Characterization of Cajanus scarabaeoides (L.) Thouars Transcriptome by Paired-End Sequencing
por: Nigam, Deepti, et al.
Publicado: (2017)

Editorial: Biomolecular solid-state NMR: Methods and applications
por: Goldbourt, Amir, et al.
Publicado: (2022)

Toll-Like Receptors Serve as Biomarkers for Early Diagnosis and Prognosis Assessment of Kidney Renal Clear Cell Carcinoma by Influencing the Immune Microenvironment: Comprehensive Bioinformatics Analysis Combined With Experimental Validation
por: Zou, Xiong, et al.
Publicado: (2022)

Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics
por: Sarohi, Vivek, et al.
Publicado: (2022)

Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
por: Scioli Montoto, Sebastián, et al.
Publicado: (2020)

Nanodomain Clustering of the Plant Protein Remorin by Solid-State NMR
por: Legrand, Anthony, et al.
Publicado: (2019)

Comprehensive Analysis of Aquaporin Superfamily in Lung Adenocarcinoma
por: Lin, Guofu, et al.
Publicado: (2021)

Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors
por: Steer, Alizée, et al.
Publicado: (2019)

Emerging Contributions of Solid-State NMR Spectroscopy to Chromatin Structural Biology
por: Ackermann, Bryce E., et al.
Publicado: (2021)

Editorial: Cancer diagnostics in solid tumors-from pathology to precision oncology
por: Malapelle, Umberto, et al.
Publicado: (2023)

The influence of the ultrasonic treatment of working fluids on electrospun amorphous solid dispersions
por: Wang, Haibin, et al.
Publicado: (2023)

Comprehensive overview of the role of PBX1 in mammalian kidneys
por: Zou, Fei, et al.
Publicado: (2023)

Deuteron Chemical Exchange Saturation Transfer for the Detection of Slow Motions in Rotating Solids
por: Vugmeyster, Liliya, et al.
Publicado: (2021)

Dihedral Angle Measurements for Structure Determination by Biomolecular Solid-State NMR Spectroscopy
por: van der Wel, Patrick C. A.
Publicado: (2021)

Comprehensive Analyses of Ferroptosis-Related Alterations and Their Prognostic Significance in Glioblastoma
por: Tian, Yuan, et al.
Publicado: (2022)

Comprehensive Pan-Cancer Analysis of Senescence With Cancer Prognosis and Immunotherapy
por: Zhao, Qinfei, et al.
Publicado: (2022)

Comprehensive analysis of the prognostic value and functions of prefoldins in hepatocellular carcinoma
por: Ke, Shanjia, et al.
Publicado: (2022)

Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studies
por: Kunert, Britta, et al.
Publicado: (2014)

Sedimentation Yields Long-Term Stable Protein Samples as Shown by Solid-State NMR
por: Wiegand, Thomas, et al.
Publicado: (2020)

Multimodal ultrasound fusion network for differentiating between benign and malignant solid renal tumors
por: Zhu, Dongmei, et al.
Publicado: (2022)

RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases
por: Magnusson, Rasmus, et al.
Publicado: (2022)

Pyroptosis in sepsis: Comprehensive analysis of research hotspots and core genes in 2022
por: Xia, Demeng, et al.
Publicado: (2022)

Profiling Thermus thermophilus Argonaute Guide DNA Sequence Preferences by Functional Screening
por: Hunt, Eric A., et al.
Publicado: (2021)

Characterization of silk genes in Ephestia kuehniella and Galleria mellonella revealed duplication of sericin genes and highly divergent sequences encoding fibroin heavy chains
por: Wu, Bulah Chia-hsiang, et al.
Publicado: (2022)

Immunometabolic Dysfunction of Natural Killer Cells Mediated by the Hypoxia-CD73 Axis in Solid Tumors
por: Chambers, Andrea M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_30snjj1b2hofpiog1clomth6dc