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Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

The 3′-to-5′ exoribonuclease in coronavirus (CoV) nonstructural protein 14 (nsp14-ExoN) mediates RNA proofreading during genome replication. ExoN catalytic residues are arranged in three motifs: I (DE), II (E), and III (D). Alanine replacement of the motif I residues (AA-E-D; four nucleotide substit...

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Detalles Bibliográficos
Autores principales:	Graepel, Kevin W., Agostini, Maria L., Lu, Xiaotao, Sexton, Nicole R., Denison, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798108/ https://www.ncbi.nlm.nih.gov/pubmed/31341046 http://dx.doi.org/10.1128/JVI.00711-19

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