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Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8(+) T lymphocyte exhaustion

BACKGROUND: Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cells. In activated lymphocytes, LAG3 expression is involved in negative control o...

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Detalles Bibliográficos
Autores principales:	Ascione, Alessandro, Arenaccio, Claudia, Mallano, Alessandra, Flego, Michela, Gellini, Mara, Andreotti, Mauro, Fenwick, Craig, Pantaleo, Giuseppe, Vella, Stefano, Federico, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798348/ https://www.ncbi.nlm.nih.gov/pubmed/31623599 http://dx.doi.org/10.1186/s12896-019-0559-x

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