pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

BACKGROUND: Multidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P-gp) that reduce the intracellular accumulation of various chemotherapeutic age...

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Detalles Bibliográficos
Autores principales: Zhang, Sipei, Guo, Nan, Wan, Guoyun, Zhang, Tao, Li, Chunyu, Wang, Yongfei, Wang, Yinsong, Liu, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798417/
https://www.ncbi.nlm.nih.gov/pubmed/31623608
http://dx.doi.org/10.1186/s12951-019-0540-9

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