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2325 Targeting isoform-specific PI3 kinase signaling for treatment of cutaneous T cell lymphoma

OBJECTIVES/SPECIFIC AIMS: (1) Determine the anti-proliferative effect of Copanlisib (α/δ PI3 kinase inhibitor) in CTCL cell lines and synergy with other anti-tumor drugs such as HDAC inhibitors. (2) Determine the effect of Copanlisib treatment on downstream targets of the PI3K/AKT/mTOR pathway. METH...

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Detalles Bibliográficos
Autores principales:	Raychaudhuri, Suravi, Wu, Chi-Heng, Ai, Weiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Basic/Translational Science/Team Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798446/ http://dx.doi.org/10.1017/cts.2018.128

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