Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

BACKGROUND: Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in active DNA demethylation. Here, we investigate whether oral vitamin C suppleme...

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Detalles Bibliográficos
Autores principales: Gillberg, Linn, Ørskov, Andreas D., Nasif, Ammar, Ohtani, Hitoshi, Madaj, Zachary, Hansen, Jakob W., Rapin, Nicolas, Mogensen, Johanne B., Liu, Minmin, Dufva, Inge H., Lykkesfeldt, Jens, Hajkova, Petra, Jones, Peter A., Grønbæk, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798470/
https://www.ncbi.nlm.nih.gov/pubmed/31623675
http://dx.doi.org/10.1186/s13148-019-0739-5

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